ChemicalBook > CAS DataBase List > TP0463518

TP0463518

Product Name
TP0463518
CAS No.
1558021-37-6
Chemical Name
TP0463518
Synonyms
BGE-117;TP0463518;TP0463518, 10 mM in DMSO;HIF-PH,TP 0463518,TP0463518,TP-0463518,HIFs,inhibit,Inhibitor,HIF/HIF Prolyl-Hydroxylase,Hypoxia-inducible factors;Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-;2-(1-((6-(4-Chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxamido)acetic acid
CBNumber
CB34656567
Molecular Formula
C20H18ClN3O6
Formula Weight
431.83
MOL File
1558021-37-6.mol
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TP0463518 Property

Boiling point:
775.8±60.0 °C(Predicted)
Density 
1.512±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:40.0(Max Conc. mg/mL);92.63(Max Conc. mM)
form 
A solid
pka
3.63±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0043483
Product name
TP0463518
Purity
98.02%
Packaging
5mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0043483
Product name
TP0463518
Purity
98.02%
Packaging
10mg
Price
$750
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573277
Product name
TP0463518
Purity
>98%
Packaging
100mg
Price
$986
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573277
Product name
TP0463518
Purity
>98%
Packaging
250mg
Price
$1654.1
Updated
2021/12/16
ChemScene
Product number
CS-0043483
Product name
TP0463518
Purity
98.02%
Packaging
50mg
Price
$2250
Updated
2021/12/16
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TP0463518 Chemical Properties,Usage,Production

Uses

TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1].

References

[1] Kato S, et al. TP0463518, a novel inhibitor for hypoxia-inducible factor prolyl hydroxylases, increases erythropoietin in rodents and monkeys with a good pharmacokinetics-pharmacodynamics correlation. Eur J Pharmacol. 2018 Nov 5;838:138-144. DOI:10.1016/j.ejphar.2018.08.044

TP0463518 Preparation Products And Raw materials

Raw materials

Preparation Products

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TP0463518 Suppliers

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1558021-37-6, TP0463518Related Search:


  • TP0463518
  • Glycine, N-[[1-[[6-(4-chlorophenoxy)-3-pyridinyl]methyl]-1,2,5,6-tetrahydro-4-hydroxy-2-oxo-3-pyridinyl]carbonyl]-
  • BGE-117
  • HIF-PH,TP 0463518,TP0463518,TP-0463518,HIFs,inhibit,Inhibitor,HIF/HIF Prolyl-Hydroxylase,Hypoxia-inducible factors
  • 2-(1-((6-(4-Chlorophenoxy)pyridin-3-yl)methyl)-4-hydroxy-2-oxo-1,2,5,6-tetrahydropyridine-3-carboxamido)acetic acid
  • TP0463518, 10 mM in DMSO
  • 1558021-37-6
  • 1558021-37-0