2H-Pyrrolo[2,3-b]pyridin-2-one, 6-chloro-1,3-dihydro-3,3-dimethyl-
- Product Name
- 2H-Pyrrolo[2,3-b]pyridin-2-one, 6-chloro-1,3-dihydro-3,3-dimethyl-
- CAS No.
- 1581754-84-8
- Chemical Name
- 2H-Pyrrolo[2,3-b]pyridin-2-one, 6-chloro-1,3-dihydro-3,3-dimethyl-
- Synonyms
- 6-chloro-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2-one;6-Chloro-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;6-chloro-3,3-dimethyl-1H,2H,3H-pyrrolo[2,3-b]pyridin-2-one;6-Chloro-3,3-dimethyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one;2H-Pyrrolo[2,3-b]pyridin-2-one, 6-chloro-1,3-dihydro-3,3-dimethyl-
- CBNumber
- CB34664324
- Molecular Formula
- C9H9ClN2O
- Formula Weight
- 196.63
- MOL File
- 1581754-84-8.mol
2H-Pyrrolo[2,3-b]pyridin-2-one, 6-chloro-1,3-dihydro-3,3-dimethyl- Property
- Boiling point:
- 349.7±42.0 °C(Predicted)
- Density
- 1.271±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 11.86±0.40(Predicted)
- Appearance
- Off-white to pink Solid
N-Bromosuccinimide Price
- Product number
- 2845EB
- Product name
- 6-Chloro-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
- Packaging
- 5g
- Price
- $3165
- Updated
- 2021/12/16
- Product number
- A447052
- Product name
- 6-Chloro-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
- Purity
- 95%
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CD11373522
- Product name
- 6-Chloro-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
- Purity
- 95%
- Packaging
- 100mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- A447052
- Product name
- 6-Chloro-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
- Purity
- 95%
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- CM336593
- Product name
- 6-Chloro-3,3-dimethyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one
- Purity
- 95%+
- Packaging
- 100mg
- Price
- $187
- Updated
- 2021/12/16
2H-Pyrrolo[2,3-b]pyridin-2-one, 6-chloro-1,3-dihydro-3,3-dimethyl- Chemical Properties,Usage,Production
Synthesis
220896-14-0
74-88-4
1581754-84-8
a) A suspension of anhydrous THF (10.5 mL) of potassium tert-butoxide (3.2 g, 28.0 mmol) was mixed with a suspension of anhydrous THF (8.1 mL) of 6-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one (1 g, 5.59 mmol) under argon protection and ice-bath cooling conditions. Subsequently, copper(I)-dimethyl sulfide bromide complex (116 mg, 559 μmol) was added. A solution of THF (1 mL) in iodomethane (1.59 g, 11.2 mmol) was added slowly and dropwise over 15 min at the same temperature. After removing the ice bath, the reaction mixture was stirred at room temperature for 30 min. After that, the reaction mixture was cooled to 0 °C and saturated aqueous NH4Cl solution (20 mL) was added. The aqueous phase was extracted with EtOAc, the organic layers were combined, washed with water, dried over Na2SO4 and the solvent was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using heptane/ethyl acetate as eluent to afford 6-chloro-3,3-dimethyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one as a pink solid (470 mg).MS ESI (m/z): 197.1/199.2 [(M + H)+].1H NMR (CDCl3, 300 MHz) δ= 8.13 (br s, 1H), 7.39 (d, J = 7.9 Hz, 1H), 7.00 (d, J = 7.7 Hz, 1H), 1.42 (s, 6H).
References
[1] Patent: WO2014/40969, 2014, A1. Location in patent: Page/Page column 69
[2] Patent: KR2016/37198, 2016, A. Location in patent: Paragraph 3329-3331
2H-Pyrrolo[2,3-b]pyridin-2-one, 6-chloro-1,3-dihydro-3,3-dimethyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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