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CAY10722

Product Name
CAY10722
CAS No.
388086-13-3
Chemical Name
CAY10722
Synonyms
CAY10722;CAY10722,CAY-10722;N-[2-(2,4-Dichlorophenyl)-5-benzoxazolyl]benzeneacetamide;Benzeneacetamide, N-[2-(2,4-dichlorophenyl)-5-benzoxazolyl]-
CBNumber
CB34666313
Molecular Formula
C21H14Cl2N2O2
Formula Weight
397.25
MOL File
388086-13-3.mol
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CAY10722 Property

Boiling point:
598.7±50.0 °C(Predicted)
Density 
1.406±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: Slightly soluble
form 
A crystalline solid
pka
13.04±0.43(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22404
Product name
CAY10722
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
22404
Product name
CAY10722
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
22404
Product name
CAY10722
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
22404
Product name
CAY10722
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
AK Scientific
Product number
7248CE
Product name
N-[2-(2,4-Dichlorophenyl)-1,3-benzoxazol-5-yl]-2-phenylacetamide
Packaging
10mg
Price
$370
Updated
2021/12/16
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CAY10722 Chemical Properties,Usage,Production

Description

CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 μM).1 SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type.2,3 High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load.4 In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.5

References

1. Salo, H.S., Latinen, T., Poso, A., et al. Identification of novel SIRT3 inhibitor scaffolds by virtual screening Bioorg. Med. Chem. Lett. 23(10),2990-2995(2013).
2. Chen, Y., Fu, L., Wen, X., et al. Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer Cell Death Dis. 5(e1047),1-7(2014).
3. Xiong, Y., Wang, M., Zhao, J., et al. Sirtuin 3: A Janus face in cancer (Review) Int. J. Oncol. 49(6),2227-2235(2016).
4. Zhao, Y., Yang, H., Wang, X., et al. Sirtuin-3 (SIRT3) expression is associated with overall survival in esophageal cancer Ann. Diagn. Pathol. 17(6),483-485(2013).
5. Desouki, M.M., Doubinskaia, I., Gius, D., et al. Decreased mitochondrial SIRT3 expression is potential molecular biomarker associated with poor outcome in breast cancer Hum. Pathol. 45(5),1071–1077(2014).

CAY10722 Preparation Products And Raw materials

Raw materials

Preparation Products

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CAY10722 Suppliers

China 6 United States 3 Global 9
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

388086-13-3, CAY10722Related Search:


  • CAY10722
  • N-[2-(2,4-Dichlorophenyl)-5-benzoxazolyl]benzeneacetamide
  • CAY10722,CAY-10722
  • Benzeneacetamide, N-[2-(2,4-dichlorophenyl)-5-benzoxazolyl]-
  • 388086-13-3