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DDD85646

Product Name
DDD85646
CAS No.
1215010-55-1
Chemical Name
DDD85646
Synonyms
DDD85646;DDD 85646 (DDD85646);DDD85646 Hydrochloride;2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide;Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-;2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzene-1-sulfonamide;African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite
CBNumber
CB34666388
Molecular Formula
C21H24Cl2N6O2S
Formula Weight
495.43
MOL File
1215010-55-1.mol
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DDD85646 Property

Melting point:
>215°C (dec.)
Boiling point:
684.3±65.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
pka
7.04±0.50(Predicted)
form 
Solid
color 
Off-White to Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13839
Product name
DDD85646
Purity
≥98%
Packaging
1mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
13839
Product name
DDD85646
Purity
≥98%
Packaging
5mg
Price
$410
Updated
2024/03/01
Cayman Chemical
Product number
13839
Product name
DDD85646
Purity
≥98%
Packaging
10mg
Price
$672
Updated
2024/03/01
TRC
Product number
D195323
Product name
DDD85646
Packaging
2.5mg
Price
$265
Updated
2021/12/16
Usbiological
Product number
445831
Product name
DDD85646
Packaging
1mg
Price
$410
Updated
2021/12/16
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DDD85646 Chemical Properties,Usage,Production

Description

DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT. It less potently inhibits growth of T. cruzi (EC50 = 6.9 μM).

Uses

DDD85646 is a potent inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT).

DDD85646 Preparation Products And Raw materials

Raw materials

Preparation Products

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DDD85646 Suppliers

China 31 United States 3 Global 34
Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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400-9205774
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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19129375004 15321929114
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TargetMol Chemicals Inc.
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Nanjing Shizhou Biology Technology Co.,Ltd
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RD International Technology Co., Limited
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1215010-55-1, DDD85646Related Search:


  • DDD85646
  • DDD 85646 (DDD85646)
  • Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-
  • DDD85646 Hydrochloride
  • African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite
  • 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide
  • 2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzene-1-sulfonamide
  • 1215010-55-1
  • C21H24Cl2N6O2S