ChemicalBook > CAS DataBase List > DDD85646
DDD85646
- Product Name
- DDD85646
- CAS No.
- 1215010-55-1
- Chemical Name
- DDD85646
- Synonyms
- DDD85646;DDD 85646 (DDD85646);DDD85646 Hydrochloride;2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide;Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-;African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite
- CBNumber
- CB34666388
- Molecular Formula
- C21H24Cl2N6O2S
- Formula Weight
- 495.43
- MOL File
- 1215010-55-1.mol
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DDD85646 Property
- Melting point:
- >215°C (dec.)
- Boiling point:
- 684.3±65.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly, Heated), Methanol (Slightly)
- pka
- 7.04±0.50(Predicted)
- form
- Solid
- color
- Off-White to Yellow
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 13839
- Product name
- DDD85646
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $97
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13839
- Product name
- DDD85646
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $410
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 13839
- Product name
- DDD85646
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $672
- Updated
- 2024/03/01
TRC
- Product number
- D195323
- Product name
- DDD85646
- Packaging
- 2.5mg
- Price
- $265
- Updated
- 2021/12/16
Usbiological
- Product number
- 445831
- Product name
- DDD85646
- Packaging
- 1mg
- Price
- $410
- Updated
- 2021/12/16
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DDD85646 Chemical Properties,Usage,Production
Description
DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT. It less potently inhibits growth of T. cruzi (EC50 = 6.9 μM).
Uses
DDD85646 is a potent inhibitor of Trypanosoma brucei N-myristoyltransferase (TbNMT).
DDD85646 Preparation Products And Raw materials
Raw materials
Preparation Products
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