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JJH260

Product Name
JJH260
CAS No.
1831135-30-8
Chemical Name
JJH260
Synonyms
JJH260;4-[2-(4-chlorophenyl)ethyl]-1-piperidinecarboxylicacid,7-[4-(dimethylamino)benzoyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-ylester;1-Piperidinecarboxylic acid, 4-[2-(4-chlorophenyl)ethyl]-, 7-[4-(dimethylamino)benzoyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-yl ester
CBNumber
CB34666500
Molecular Formula
C29H34ClN5O5
Formula Weight
568.06
MOL File
1831135-30-8.mol
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JJH260 Property

Boiling point:
703.9±70.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 1 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml
form 
A crystalline solid
pka
3.53±0.12(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19384
Product name
JJH260
Purity
≥90%
Packaging
500μg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
19384
Product name
JJH260
Purity
≥90%
Packaging
1mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
19384
Product name
JJH260
Purity
≥90%
Packaging
5mg
Price
$1082
Updated
2024/03/01
AK Scientific
Product number
2162DV
Product name
[7-[4-(Dimethylamino)benzoyl]-1,3-dioxo-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazin-2-yl]4-[2-(4-chlorophenyl)ethyl]piperidine-1-carboxylate
Packaging
5mg
Price
$1302
Updated
2021/12/16
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JJH260 Chemical Properties,Usage,Production

Description

JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM.1 JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2.1 JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.1

References

1. Parsons, W.H., Kolar, M.J., Kamat, S.S., et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs Nat. Chem. Biol. 12(5),367-372(2016).

JJH260 Preparation Products And Raw materials

Raw materials

Preparation Products

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JJH260 Suppliers

China 8 United States 1 Global 9
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9805
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58

1831135-30-8, JJH260Related Search:


  • JJH260
  • 1-Piperidinecarboxylic acid, 4-[2-(4-chlorophenyl)ethyl]-, 7-[4-(dimethylamino)benzoyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-yl ester
  • 4-[2-(4-chlorophenyl)ethyl]-1-piperidinecarboxylicacid,7-[4-(dimethylamino)benzoyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-ylester
  • 1831135-30-8