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JJH260

Product Name
JJH260
CAS No.
1831135-30-8
Chemical Name
JJH260
Synonyms
JJH260;4-[2-(4-chlorophenyl)ethyl]-1-piperidinecarboxylicacid,7-[4-(dimethylamino)benzoyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-ylester;1-Piperidinecarboxylic acid, 4-[2-(4-chlorophenyl)ethyl]-, 7-[4-(dimethylamino)benzoyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-yl ester
CBNumber
CB34666500
Molecular Formula
C29H34ClN5O5
Formula Weight
568.06
MOL File
1831135-30-8.mol
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JJH260 Property

Boiling point:
703.9±70.0 °C(Predicted)
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 1 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml
form 
A crystalline solid
pka
3.53±0.12(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19384
Product name
JJH260
Purity
≥90%
Packaging
500μg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
19384
Product name
JJH260
Purity
≥90%
Packaging
1mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
19384
Product name
JJH260
Purity
≥90%
Packaging
5mg
Price
$1082
Updated
2024/03/01
AK Scientific
Product number
2162DV
Product name
[7-[4-(Dimethylamino)benzoyl]-1,3-dioxo-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazin-2-yl]4-[2-(4-chlorophenyl)ethyl]piperidine-1-carboxylate
Packaging
5mg
Price
$1302
Updated
2021/12/16
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JJH260 Chemical Properties,Usage,Production

Description

JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM.1 JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2.1 JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.1

References

1. Parsons, W.H., Kolar, M.J., Kamat, S.S., et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs Nat. Chem. Biol. 12(5),367-372(2016).

JJH260 Preparation Products And Raw materials

Raw materials

Preparation Products

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JJH260 Suppliers

China 8 United States 1 Global 9
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1831135-30-8, JJH260Related Search:


  • JJH260
  • 1-Piperidinecarboxylic acid, 4-[2-(4-chlorophenyl)ethyl]-, 7-[4-(dimethylamino)benzoyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-yl ester
  • 4-[2-(4-chlorophenyl)ethyl]-1-piperidinecarboxylicacid,7-[4-(dimethylamino)benzoyl]hexahydro-1,3-dioxoimidazo[1,5-a]pyrazin-2-ylester
  • 1831135-30-8