ChemicalBook > CAS DataBase List > TTK21
TTK21
- Product Name
- TTK21
- CAS No.
- 709676-56-2
- Chemical Name
- TTK21
- Synonyms
- TTK2;TTK21;TTK21(CBP-p300 activator TTK21);Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-;TTK 21,HAT,histone acetyltransferases,neurogenesis,TTK21,blood–brain barrier,HATs,inhibit,Histone Acetyltransferase,Inhibitor,long-term memory,toxicity,CSP,TTK-21,CBP/p300
- CBNumber
- CB34666838
- Molecular Formula
- C17H15ClF3NO2
- Formula Weight
- 357.75
- MOL File
- 709676-56-2.mol
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TTK21 Property
- Boiling point:
- 369.8±42.0 °C(Predicted)
- Density
- 1.321±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 2 mg/ml
- form
- A crystalline solid
- pka
- 12.22±0.70(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C17H15ClF3NO2/c1-2-9-24-15-6-4-3-5-12(15)16(23)22-11-7-8-14(18)13(10-11)17(19,20)21/h3-8,10H,2,9H2,1H3,(H,22,23)
- InChIKey
- AQJBXYBDNZHZRE-UHFFFAOYSA-N
- SMILES
- C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)(=O)C1=CC=CC=C1OCCC
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 21959
- Product name
- TTK21
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21959
- Product name
- TTK21
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $176
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21959
- Product name
- TTK21
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $301
- Updated
- 2024/03/01
TRC
- Product number
- C428905
- Product name
- N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
- Packaging
- 1mg
- Price
- $40
- Updated
- 2021/12/16
AK Scientific
- Product number
- 7228DT
- Product name
- N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide
- Packaging
- 50mg
- Price
- $451
- Updated
- 2021/12/16
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TTK21 Chemical Properties,Usage,Production
Description
TTK21 is an activator of CBP/p300 histone acetyltransferase activity. It activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner with a maximal effect at a concentration of 275 μM, inducing acetylation of histones H3 and H4 in vitro but not H2B and H2A. TTK21, conjugated to glucose-based carbon nanospheres (CSP), crosses the blood-brain barrier and increases histone acetylation of H2B and H3 as well as H4K12 in mouse frontal cortex and H2B and H3 in the dorsal hippocampus and brainstem. CSP-TTK21 (20 mg/kg) also induces differentiation and maturation of neuronal progenitors in adult mice's subgranular zone of the dentate gyrus. It increases memory duration in the Morris water maze, with mice spending more time in the platform quadrant than untreated mice up to 16 days after learning.
Uses
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide was used in preparation of benzamide compounds as modulators of enzymes histone acetyltransferases and chromatin transcription.
TTK21 Preparation Products And Raw materials
Raw materials
Preparation Products
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