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ACT 709478

Product Name
ACT 709478
CAS No.
1838651-58-3
Chemical Name
ACT 709478
Synonyms
ACT 709478;apinocaltamide;ACT-709478 1838651-58-3;ACT 709478 (ACT709478);N-(1-((5-Cyanopyridin-2-yl)methyl)-1H-pyrazol-3-yl)-2-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)acetamide;Benzeneacetamide, N-[1-[(5-cyano-2-pyridinyl)methyl]-1H-pyrazol-3-yl]-4-[1-(trifluoromethyl)cyclopropyl]-
CBNumber
CB34667491
Molecular Formula
C22H18F3N5O
Formula Weight
425.41
MOL File
1838651-58-3.mol
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ACT 709478 Property

Boiling point:
646.4±55.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:125.0(Max Conc. mg/mL);293.83(Max Conc. mM)
form 
A solid
pka
13.52±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0045909
Product name
ACT-709478
Purity
95.00%
Packaging
5MG
Price
$459.16
Updated
2021/12/16
ChemScene
Product number
CS-0062884
Product name
ACT-709478
Purity
99.68%
Packaging
5mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0062884
Product name
ACT-709478
Purity
99.68%
Packaging
10mg
Price
$850
Updated
2021/12/16
ChemScene
Product number
CS-0062884
Product name
ACT-709478
Purity
99.68%
Packaging
50mg
Price
$2750
Updated
2021/12/16
ChemScene
Product number
CS-0062884
Product name
ACT-709478
Purity
99.68%
Packaging
100mg
Price
$3950
Updated
2021/12/16
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ACT 709478 Chemical Properties,Usage,Production

Uses

Apinocaltamide (ACT-709478) is a potent, selective, orally active, and brain penetrating T-type calcium channel blocker. ACT-709478 is used in the research of generalized epilepsies[1].

Definition

ChEBI: Apinocaltamide is a secondary carboxamide resulting from the formal condensation of the carboxy group of {4-[1-(trifluoromethyl)cyclopropyl]phenyl}acetic acid with the amino group of 6-[(3-amino-1H-pyrazol-1-yl)methyl]pyridine-3-carbonitrile. It is a selective, orally available T-type calcium channel blocker that is being studied as a potential new treatment in epilepsy. It has a role as an anticonvulsant and a T-type calcium channel blocker. It is a member of pyrazoles, a secondary carboxamide, a member of cyclopropanes, an organofluorine compound, a nitrile, a member of pyridines and a member of benzenes.

in vivo

Apinocaltamide (Compound 66b, 100, 300 mg/kg, p.o., measured 12 hours later) potently decreases the cumulative duration of absence-like seizures in mice[1].

Animal Model:Male juvenile DBA/2J mice (22-24 days old)[1]
Dosage:100, 300 mg/kg, 1 hour or 3 hours before exposure to the stimulus.
Administration:P.O., for 12 hours
Result:Decreased the cumulative duration of absence-like seizures over the next 12 h period by 93%.

IC 50

Cav1.2: 2410 nM (IC50); CaV3.1: 6.4 nM (IC50); Cav3.2: 18 nM (IC50); CaV3.3: 7.5 nM (IC50)

References

[1] Bezen?on O, et al. Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies. J Med Chem. 2017 Dec 14;60(23):9769-9789. DOI:10.1021/acs.jmedchem.7b01236

ACT 709478 Preparation Products And Raw materials

Raw materials

Preparation Products

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ACT 709478 Suppliers

China 31 United States 5 Global 36
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
Email
info@chemlin.com.cn
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China
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15724
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Shanghai Anyinuo Biomedical Technology Co., Ltd.
Tel
021-34625901 18018851262;
Email
420970979@qq.com
Country
China
ProdList
5914
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
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58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
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58
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq：1580084073
Email
1580084073@qq.com
Country
China
ProdList
983
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58
Hubei Kele Fine Chemical Co., Ltd
Tel
027-59101668 19945030958
Fax
027-59101668
Email
2881924765@qq.com
Country
China
ProdList
7970
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58

1838651-58-3, ACT 709478Related Search:


  • ACT 709478
  • ACT-709478 1838651-58-3
  • Benzeneacetamide, N-[1-[(5-cyano-2-pyridinyl)methyl]-1H-pyrazol-3-yl]-4-[1-(trifluoromethyl)cyclopropyl]-
  • ACT 709478 (ACT709478)
  • apinocaltamide
  • N-(1-((5-Cyanopyridin-2-yl)methyl)-1H-pyrazol-3-yl)-2-(4-(1-(trifluoromethyl)cyclopropyl)phenyl)acetamide
  • 1838651-58-3
  • C22H18F3N5O