ChemicalBook > CAS DataBase List > APX-115 freebase

APX-115 freebase

Product Name: APX-115 freebase
CAS No.: 1270084-92-8
Chemical Name: APX-115 freebase
Synonyms: Apx-115 free;APX-115 freebase;Ewha-18278 free base;Isuzinaxib(APX-115 free base);APX-115 free base, 10 mM in DMSO;Isuzinaxib (APX-115 free base) ，S0777;3-Phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol;1H-Pyrazol-5-ol, 3-phenyl-4-propyl-1-(2-pyridinyl)-;plasma,APX 115 free base,NOX,Inhibitor,injury,Nox1,kidney,Ewha18278,APX115,albumin,Ewha 18278,APX115 free base,insulin,Ewha-18278,Nox3,resistance,APX 115,APX-115,NADPH Oxidase,inhibit,creatinine,Nox2
CBNumber: CB34667547
Molecular Formula: C17H17N3O
Formula Weight: 279.34
MOL File: 1270084-92-8.mol

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APX-115 freebase Property

Boiling point:: 493.3±45.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml
form: Solid
pka: 7?+-.0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0087247
Product name: APX-115(freebase)
Purity: 99.47%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0087247
Product name: APX-115(freebase)
Purity: 99.47%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0087247
Product name: APX-115(freebase)
Purity: 99.47%
Packaging: 25mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0087247
Product name: APX-115(freebase)
Purity: 99.47%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0087247
Product name: APX-115(freebase)
Purity: 99.47%
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

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APX-115 freebase Chemical Properties,Usage,Production

Uses

APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1].

in vivo

APX-115 free base (oral gavage; 60?mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice^[2].
APX-115 free base treatment decreases the urinary excretion of albumin and plasma creatinine levels^[2].

Animal Model:	Six-week-old male diabetic db/db mice (C57BLKS/J-lepr^db/lepr^db)^[2]
Dosage:	60?mg/kg
Administration:	Oral gavage; per day; for 12 weeks
Result:	Significantly improved insulin resistance in diabetic mice.

IC 50

NOX1; NOX2; NOX4

References

[1] Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232. DOI:10.18632/oncotarget.18540
[2] Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431. DOI:10.1038/labinvest.2017.2
[3] J. JOO. A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase[J]. Scientific Reports, 2016, 6 1. DOI: 10.1038/srep22389

APX-115 freebase Preparation Products And Raw materials

Raw materials

Preparation Products

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1270084-92-8, APX-115 freebaseRelated Search:

5,5-Diphenylhydantoin

APX-115 freebase

Ewha-18278 free base

1H-Pyrazol-5-ol, 3-phenyl-4-propyl-1-(2-pyridinyl)-

3-Phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol

plasma,APX 115 free base,NOX,Inhibitor,injury,Nox1,kidney,Ewha18278,APX115,albumin,Ewha 18278,APX115 free base,insulin,Ewha-18278,Nox3,resistance,APX 115,APX-115,NADPH Oxidase,inhibit,creatinine,Nox2

Isuzinaxib(APX-115 free base)

APX-115 free base, 10 mM in DMSO

Apx-115 free

Isuzinaxib (APX-115 free base) ，S0777

1270084-92-8