AZ-8838

Product Name: AZ-8838
CAS No.: 2100285-41-2
Chemical Name: AZ-8838
Synonyms: AZ-8838;(R)-(4-Fluoro-2-propylphenyl)(1H-imidazol-2- yl)methanol;1H-Imidazole-2-methanol, α-(4-fluoro-2-propylphenyl)-, (αS)-
CBNumber: CB34667587
Molecular Formula: C13H15FN2O
Formula Weight: 234.27
MOL File: 2100285-41-2.mol

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AZ-8838 Property

Boiling point:: 440.3±45.0 °C(Predicted)
Density: 1.219±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 12.47±0.20(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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AZ-8838 Chemical Properties,Usage,Production

Biological Activity

AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pKi of 6.4 for hPAR2[1]. AZ8838 binds in an occluded pocket[1].AZ8838 is a potent antagonist against SLIGRL-NH2 in the Ca2+ assay with a pIC50 of 5.70 ± 0.02[1].AZ8838 shows a potency trend when inhibiting IP1 production (pIC50 = 5.84 ± 0.02)[1].AZ8838 attenuates both peptide-induced phosphorylation of ERK1/2 (pIC50 = 5.7 ± 0.1) and β-arrestin-2 recruitment (pIC50 = 6.1 ± 0.1)[1]. AZ8838 (10 mg/kg; p.o.; 2 h prior) is anti-inflammatory in a PAR2 agonist-induced rat paw oedema model[1].

References

[1]. Kennedy AJ, et al. Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition. Commun Biol. 2020 Dec 17;3(1):782.

AZ-8838 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZ-8838 Suppliers

China 11 United States 2 Global 13

Shanghai EFE Biological Technology Co., Ltd.

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Aladdin Scientific

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2100285-41-2, AZ-8838Related Search:

AZ-8838

(R)-(4-Fluoro-2-propylphenyl)(1H-imidazol-2- yl)methanol

1H-Imidazole-2-methanol, α-(4-fluoro-2-propylphenyl)-, (αS)-

2100285-41-2