JHU-083
- Product Name
- JHU-083
- CAS No.
- 1998725-11-3
- Chemical Name
- JHU-083
- Synonyms
- T15613;JHU-083;JHU-083 ，S8891;JHU083;JHU 083
- CBNumber
- CB34668069
- Molecular Formula
- C14H24N4O4
- Formula Weight
- 312.37
- MOL File
- 1998725-11-3.mol
JHU-083 Property
- storage temp.
- Store at -20°C, protect from light, stored under nitrogen
- solubility
- DMSO: 100 mg/mL (320.14 mM)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-0082730
- Product name
- JHU-083
- Purity
- >97.0%
- Packaging
- 1mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- CS-0082730
- Product name
- JHU-083
- Purity
- >97.0%
- Packaging
- 5mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- CS-0082730
- Product name
- JHU-083
- Purity
- >97.0%
- Packaging
- 10mg
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- DC11230
- Product name
- JHU-083
- Purity
- >98%
- Packaging
- 1g
- Price
- $3600
- Updated
- 2021/12/16
JHU-083 Chemical Properties,Usage,Production
Uses
JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals[1][2].
in vivo
JHU-083 (1.82 mg/kg; PO; every other day for 12 days) ameliorates social avoidance behavior and anhedonia-like behavior induced by CSDS[1].
JHU-083 (1.82 mg/kg, PO) attenuates CSDS-induced increase in glutaminase activity in CD11b+ cells in the prefrontal cortex and hippocampus, but not in the cerebellum. JHU-083 treatment suppresses the CSDS-induced upregulation of IL-1β and TNF-α expression[1].
| Animal Model: | Male 7-to 8-week-old C57BL/6J (C57) mice (25-30g) with chronic social defeat stress (CSDS)[1] |
| Dosage: | 1.82mg/kg |
| Administration: | PO; every other day for 12 days |
| Result: | Ameliorated social avoidance behavior and anhedonia-like behavior induced by CSDS. |
References
[1] Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. DOI:10.1038/s41386-018-0177-7
[2] Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033. DOI:10.1073/pnas.1812909115
JHU-083 Preparation Products And Raw materials
Raw materials
Preparation Products
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