LIT-001

Product Name: LIT-001
CAS No.: 2245072-21-1
Chemical Name: LIT-001
Synonyms: LIT-001;LIT-001 TFA;LIT-001, 10 mM in DMSO;LIT-001 trifluoroacetate;LIT-001 trifluoroacetate ，E0620;LIT 001,autism,LIT001,Inhibitor,interaction,inhibit,OXTR,V1a,vasopressin,nonpeptide,social,nonbiased,LIT-001,receptor,Oxytocin Receptor,disorders,spectrum;(S)-2-(Dimethylcarbamothioyl)-N-(2-methyl-4-(1-methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine-5-carbonyl)benzyl)pyrrolidine-1-carboxamide, Trifluoroacetate;(S)-2-(Dimethylcarbamothioyl)-N-(2-methyl-4-(1-methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine-5-carbonyl)benzyl)pyrrolidine-1-carboxamide 2,2,2-trifluoroacetate
CBNumber: CB34668135
Molecular Formula: C30H34F3N7O4S
Formula Weight: 645.7
MOL File: 2245072-21-1.mol

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LIT-001 Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:250.0(Max Conc. mg/mL);387.18(Max Conc. mM)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0087519
Product name: LIT-001
Purity: 98.52%
Packaging: 5mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0087519
Product name: LIT-001
Purity: 98.52%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0087519
Product name: LIT-001
Purity: 98.52%
Packaging: 25mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0087519
Product name: LIT-001
Purity: 98.52%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0087519
Product name: LIT-001
Purity: 98.52%
Packaging: 100mg
Price: $1450
Updated: 2021/12/16

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LIT-001 Chemical Properties,Usage,Production

Uses

LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 improves social interaction in a mouse model of autism[1].

in vivo

LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD )^[1].

Animal Model:	Oprm1^–/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background)^[1]
Dosage:	10, 20 mg/kg
Administration:	i.p.
Result:	Alleviated core symptoms in the context of ASD.

References

[1] Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61(19):8670-8692. DOI:10.1021/acs.jmedchem.8b00697

LIT-001 Preparation Products And Raw materials

Raw materials

Preparation Products

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LIT-001 Suppliers

China 29 United States 4 Global 33

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
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ProdList: 71826
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
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Shanghai hongqu biomedical technology co. LTD

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Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
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2245072-21-1, LIT-001Related Search:

LIT-001

LIT-001 TFA

LIT 001,autism,LIT001,Inhibitor,interaction,inhibit,OXTR,V1a,vasopressin,nonpeptide,social,nonbiased,LIT-001,receptor,Oxytocin Receptor,disorders,spectrum

(S)-2-(Dimethylcarbamothioyl)-N-(2-methyl-4-(1-methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine-5-carbonyl)benzyl)pyrrolidine-1-carboxamide 2,2,2-trifluoroacetate

LIT-001, 10 mM in DMSO

(S)-2-(Dimethylcarbamothioyl)-N-(2-methyl-4-(1-methyl-1,4,5,10-tetrahydrobenzo[b]pyrazolo[3,4-e][1,4]diazepine-5-carbonyl)benzyl)pyrrolidine-1-carboxamide, Trifluoroacetate

LIT-001 trifluoroacetate

LIT-001 trifluoroacetate ，E0620

2245072-21-1