ChemicalBook > CAS DataBase List > MK-8353

MK-8353

Product Name
MK-8353
CAS No.
1184173-73-6
Chemical Name
MK-8353
Synonyms
MK-8353;SCH900353;SCH-900565;MK-8353 (SCH900353);SCH900353 (MK-8353);MK-8353, 10 mM in DMSO;SCH 900353,Extracellular signal regulated kinases,Inhibitor,inhibit,MK 8353,SCH-900353,MK-8353,ERK,MK8353;(S)-N-(3-(6-Isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide;3-Pyrrolidinecarboxamide, 1-[2-[3,6-dihydro-4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-1(2H)-pyridinyl]-2-oxoethyl]-N-[3-[6-(1-methylethoxy)-3-pyridinyl]-1H-indazol-5-yl]-3-(methylthio)-, (3S)-
CBNumber
CB34668195
Molecular Formula
C37H41N9O3S
Formula Weight
691.84
MOL File
1184173-73-6.mol
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MK-8353 Property

Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO
pka
11.89±0.40(Predicted)
form 
Solid
color 
Off-white to light brown
InChIKey
KPQQGHGDBBJGFA-QNGWXLTQSA-N
SMILES
N1(CC(N2CCC(C3=CC=C(C4N=CN(C)N=4)C=C3)=CC2)=O)CC[C@@](SC)(C(NC2C=CC3=C(C=2)C(C2=CC=C(OC(C)C)N=C2)=NN3)=O)C1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
BISN0200
Product name
MK-8353
Packaging
2mg
Price
$149
Updated
2021/12/16
ChemScene
Product number
CS-0040548
Product name
MK-8353
Purity
98.79%
Packaging
5mg
Price
$175
Updated
2021/12/16
Apolloscientific
Product number
BISN0200
Product name
MK-8353
Packaging
5mg
Price
$284
Updated
2021/12/16
Apolloscientific
Product number
BISN0200
Product name
MK-8353
Packaging
25mg
Price
$804
Updated
2021/12/16
ChemScene
Product number
CS-0040548
Product name
MK-8353
Purity
98.79%
Packaging
50mg
Price
$1260
Updated
2021/12/16
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MK-8353 Chemical Properties,Usage,Production

Uses

MK-8353 (SCH900353) is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity.

Definition

ChEBI: MK-8353 is a member of the class of indazoles that is 1H-indazole substituted by a 6-(propan-2-yloxy)pyridin-3-yl group at position 3 and by a {[(3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)pyrrolidin-3-yl]carbonyl}amino group at position 5. It is a potent and selective inhibitor of ERK1 and ERK2 in vitro (IC50 values of 23.0 nM and 8.8 nM, respectively). The drug is being developed by Merck Sharp & Dohme and is currently in clinical development for the treatment of advanced/metastatic solid tumors. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of indazoles, a member of triazoles, a dihydropyridine, a member of pyridines, an aromatic ether, a secondary carboxamide, a pyrrolidinecarboxamide, a N-alkylpyrrolidine, a methyl sulfide and a tertiary carboxamide.

in vivo

MK-8353 (60 mg/kg, p.o., bid (twice daily)) causes at least 50% tumor growth inhibition or regression in 83% of the animal models bearing different tumor cells, including LOX, Colo-205, MIA PaCa-2, and Calu-6 cells[1].

IC 50

ERK2: 8.8 nM (IC50); ERK1: 23 nM (IC50)

References

[1] Moschos SJ, et al. Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors. JCI Insight. 2018 Feb 22;3(4). pii: 92352. DOI:10.1172/jci.insight.92352

MK-8353 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-8353 Suppliers

China 61 United States 5 Global 66
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
DKMbiochem.Co. Ltd
Tel
15901859516
Fax
15901859516
Email
sales@DKMbiochem.com
Country
China
ProdList
344
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4769
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
984
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58

1184173-73-6, MK-8353Related Search:

MK-1775 MK-0941 MK-2206 2HCl MK-3903

  • MK-8353
  • SCH-900565
  • SCH900353
  • MK-8353 (SCH900353)
  • 3-Pyrrolidinecarboxamide, 1-[2-[3,6-dihydro-4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-1(2H)-pyridinyl]-2-oxoethyl]-N-[3-[6-(1-methylethoxy)-3-pyridinyl]-1H-indazol-5-yl]-3-(methylthio)-, (3S)-
  • SCH 900353,Extracellular signal regulated kinases,Inhibitor,inhibit,MK 8353,SCH-900353,MK-8353,ERK,MK8353
  • (S)-N-(3-(6-Isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide
  • SCH900353 (MK-8353)
  • MK-8353, 10 mM in DMSO
  • 1184173-73-6
  • C37H41N9O3S