MK-8353

Product Name: MK-8353
CAS No.: 1184173-73-6
Chemical Name: MK-8353
Synonyms: MK-8353;SCH900353;SCH-900565;MK-8353 (SCH900353);SCH900353 (MK-8353);SCH 900353,Extracellular signal regulated kinases,Inhibitor,inhibit,MK 8353,SCH-900353,MK-8353,ERK,MK8353;(S)-N-(3-(6-Isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide;3-Pyrrolidinecarboxamide, 1-[2-[3,6-dihydro-4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-1(2H)-pyridinyl]-2-oxoethyl]-N-[3-[6-(1-methylethoxy)-3-pyridinyl]-1H-indazol-5-yl]-3-(methylthio)-, (3S)-
CBNumber: CB34668195
Molecular Formula: C37H41N9O3S
Formula Weight: 691.84
MOL File: 1184173-73-6.mol

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MK-8353 Property

Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO
pka: 11.89±0.40(Predicted)
form: Solid
color: Off-white to light brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: BISN0200
Product name: MK-8353
Packaging: 2mg
Price: $149
Updated: 2021/12/16

ChemScene

Product number: CS-0040548
Product name: MK-8353
Purity: 98.79%
Packaging: 5mg
Price: $175
Updated: 2021/12/16

Apolloscientific

Product number: BISN0200
Product name: MK-8353
Packaging: 5mg
Price: $284
Updated: 2021/12/16

Apolloscientific

Product number: BISN0200
Product name: MK-8353
Packaging: 25mg
Price: $804
Updated: 2021/12/16

ChemScene

Product number: CS-0040548
Product name: MK-8353
Purity: 98.79%
Packaging: 50mg
Price: $1260
Updated: 2021/12/16

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MK-8353 Chemical Properties,Usage,Production

Definition

ChEBI: MK-8353 is a member of the class of indazoles that is 1H-indazole substituted by a 6-(propan-2-yloxy)pyridin-3-yl group at position 3 and by a {[(3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)pyrrolidin-3-yl]carbonyl}amino group at position 5. It is a potent and selective inhibitor of ERK1 and ERK2 in vitro (IC50 values of 23.0 nM and 8.8 nM, respectively). The drug is being developed by Merck Sharp & Dohme and is currently in clinical development for the treatment of advanced/metastatic solid tumors. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a member of indazoles, a member of triazoles, a dihydropyridine, a member of pyridines, an aromatic ether, a secondary carboxamide, a pyrrolidinecarboxamide, a N-alkylpyrrolidine, a methyl sulfide and a tertiary carboxamide.

MK-8353 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-8353 Suppliers

China 46 United States 5 Global 51

Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
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DKMbiochem.Co. Ltd

Tel: 15901859516
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Email: sales@DKMbiochem.com
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AdooQ Bioscience CHINA

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Shanghai Lollane Biological Technology Co.,Ltd.

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ShangHai Biochempartner Co.,Ltd

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Fan De(Beijing) Biotechnology Co., Ltd.

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1184173-73-6, MK-8353Related Search:

MK-1775 MK-0941 MK-2206 2HCl MK-3903

MK-8353

SCH-900565

SCH900353

MK-8353 (SCH900353)

3-Pyrrolidinecarboxamide, 1-[2-[3,6-dihydro-4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-1(2H)-pyridinyl]-2-oxoethyl]-N-[3-[6-(1-methylethoxy)-3-pyridinyl]-1H-indazol-5-yl]-3-(methylthio)-, (3S)-

SCH 900353,Extracellular signal regulated kinases,Inhibitor,inhibit,MK 8353,SCH-900353,MK-8353,ERK,MK8353

(S)-N-(3-(6-Isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide

SCH900353 (MK-8353)

1184173-73-6

C37H41N9O3S