Ogerin
- Product Name
- Ogerin
- CAS No.
- 1309198-71-7
- Chemical Name
- Ogerin
- Synonyms
- Ogerin;Ogerin >=98% (HPLC);2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol;Benzenemethanol, 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-;G Protein-Coupled Receptor 68,Inhibitor,TGF-β,inhibit,fibroblasts,fibrotic diseases,Ogerin,GPR68,HEK293,A2A
- CBNumber
- CB34670516
- Molecular Formula
- C17H17N5O
- Formula Weight
- 307.35
- MOL File
- 1309198-71-7.mol
Ogerin Property
- storage temp.
- 2-8°C
- solubility
- DMSO: 50 mg/ml
- form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML1482
- Product name
- Ogerin
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $105
- Updated
- 2023/06/20
- Product number
- SML1482
- Product name
- Ogerin
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $424
- Updated
- 2023/06/20
- Product number
- 5722
- Product name
- Ogerin
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $724
- Updated
- 2021/12/16
- Product number
- 5722
- Product name
- Ogerin
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $173
- Updated
- 2021/12/16
- Product number
- O990035
- Product name
- Ogerin
- Packaging
- 1mg
- Price
- $95
- Updated
- 2021/12/16
Ogerin Chemical Properties,Usage,Production
Uses
Ogerin is a potent GPR68 modulator.
Biochem/physiol Actions
Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory.
Enzyme inhibitor
This GPR68 activator (FW = 307.35 g/mol; CAS 1309198-71-7), also named 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol, selectively and allosterically targets G-Protein-coupled Receptor 68, one of at least 120 non-olfactory G-protein-coupled receptors in the human genome that remain 'orphans' (i.e., they are pharmacologically dark, with no known endogenous ligands). Ogerin suppresses recall in fear conditioning in wild-type, but not in GPR68-knockout mice. GPR68 is also a newly recognized metastasis suppressor gene in certain cancers.
storage
Store at -20°C