8-Hydroxymethyl guanosine

Product Name: 8-Hydroxymethyl guanosine
CAS No.: 54898-41-8
Chemical Name: 8-Hydroxymethyl guanosine
Synonyms: 8-Hydroxymethyl guanosine;Guanosine, 8-(hydroxymethyl)-;2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-(hydroxymethyl)-1,9-dihydro-6H-purin-6-one
CBNumber: CB34672499
Molecular Formula: C11H15N5O6
Formula Weight: 313.27
MOL File: 54898-41-8.mol

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8-Hydroxymethyl guanosine Property

Density: 2.25±0.1 g/cm3(Predicted)
pka: 9.61±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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8-Hydroxymethyl guanosine Chemical Properties,Usage,Production

Uses

8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100

8-Hydroxymethyl guanosine Preparation Products And Raw materials

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Preparation Products

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54898-41-8, 8-Hydroxymethyl guanosineRelated Search:

8-Hydroxymethyl guanosine

Guanosine, 8-(hydroxymethyl)-

2-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-8-(hydroxymethyl)-1,9-dihydro-6H-purin-6-one

54898-41-8