5-(Trifluoromethyl)-1H-1,2,3-triazole
- Product Name
- 5-(Trifluoromethyl)-1H-1,2,3-triazole
- CAS No.
- 40964-54-3
- Chemical Name
- 5-(Trifluoromethyl)-1H-1,2,3-triazole
- Synonyms
- 5-trifluoromethyl-1,2,3-triazole;4-(trifluoromethyl)-1H-1,2,3-triazole;5-(Trifluoromethyl)-1H-1,2,3-triazole;1H-1,2,3-Triazole, 5-(trifluoromethyl)-;1H-1,2,3-Triazole, 4-(trifluoromethyl)-
- CBNumber
- CB34674428
- Molecular Formula
- C3H2F3N3
- Formula Weight
- 137.06
- MOL File
- 40964-54-3.mol
5-(Trifluoromethyl)-1H-1,2,3-triazole Property
- Melting point:
- 83 °C
- Boiling point:
- 183.1±35.0 °C(Predicted)
- Density
- 1.79 g/cm3
- pka
- 6.43±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4042DA
- Product name
- 5-(Trifluoromethyl)-1H-1,2,3-triazole
- Packaging
- 25mg
- Price
- $586
- Updated
- 2021/12/16
- Product number
- 4042DA
- Product name
- 5-(Trifluoromethyl)-1H-1,2,3-triazole
- Packaging
- 250mg
- Price
- $1418
- Updated
- 2021/12/16
- Product number
- CD11127452
- Product name
- 5-(Trifluoromethyl)-1H-1,2,3-triazole
- Purity
- 95+%
- Packaging
- 50mg
- Price
- $740
- Updated
- 2021/12/16
- Product number
- CD11127452
- Product name
- 5-(Trifluoromethyl)-1H-1,2,3-triazole
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- CD11127452
- Product name
- 5-(Trifluoromethyl)-1H-1,2,3-triazole
- Purity
- 95+%
- Packaging
- 10mg
- Price
- $365
- Updated
- 2021/12/16
5-(Trifluoromethyl)-1H-1,2,3-triazole Chemical Properties,Usage,Production
Definition
5-(Trifluoromethyl)-1H-1,2,3-triazole is a fluorinated triazole derivative. Triazoles are an important class of organic compounds, playing an important role in modern medicinal chemistry. Compounds with 1,2,3- and 1,2,4-triazole moieties are known to possess fungicidal, antimicrobial, anticonvulsant, antidepressant, antibacterial, anti-inflammatory, analgesic and antitumor activities[1].
Synthesis
A mixture of 1H-1,2,3-Triazole-4-carboxylic Acid (39.0 g, 345 mmol), anhyd HF (50 mL) and SF4 (46.5 g, 430 mmol) in a 500-mL autoclave was heated at 120 °C (oil bath temperature) for 16 h. The reaction mixture was cooled to 0 °C and the autoclave was then opened. The residue was put on a Teflon plate; after the residual HF had been removed by heating at 30 °C for 1–2 h (CAUTION! This procedure must be carried out in a fume hood!), the product was dissolved in CH2Cl2 (300 mL) to remove all insoluble materials. The solution was evaporated under vacuum and the thus-formed tarry residue was purified by double sublimation (20 mmHg, ～80–90 °C) to give 5-(Trifluoromethyl)-1H-1,2,3-triazole (30.3 g, 221 mmol, 64%) as a white solid[1].
References
[1] Mykhailiuk P, et al. Novel Synthetic Approaches to (Trifluoromethyl)triazoles. Synthesis, 2010; 7: 1075-1077.
5-(Trifluoromethyl)-1H-1,2,3-triazole Preparation Products And Raw materials
Raw materials
Preparation Products
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