ChemicalBook > CAS DataBase List > 7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE

7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE

Product Name: 7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE
CAS No.: 192869-80-0
Chemical Name: 7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE
Synonyms: 7-benzyl-4-chloro-5;7-Benzyl-4-chloro-5,6,7,8-tetrahydro-quinazoline;7-benzyl-4-chloro-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine;7-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIDINE;7-Benzyl-5,6,7,8-tetrahydro4-chloro-pyrido[3,4-D]pyriMidine;7-Benzyl-4-chloro-5,6,7,8-tetrahydro-1,3,7-triazanaphthalene;4-Chloro-5,6,7,8-tetrahydro-7-(benzyl)-pyrido[3,4-d]pyrimidine;7-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE HCL;4-Chloro-5,6,7,8-tetrahydro-7-(phenylmethyl)pyrido[3,4-d]pyrimidine;Pyrido[3,4-d]pyriMidine,4-chloro-5,6,7,8-tetrahydro-7-(phenylMethyl)-
CBNumber: CB3469240
Molecular Formula: C14H14ClN3
Formula Weight: 259.73
MOL File: 192869-80-0.mol

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7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE Property

Boiling point:: 396.6±42.0 °C(Predicted)
Density: 1.273±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 5.22±0.20(Predicted)
Appearance: Yellow to brown Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B233775
Product name: 7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine
Packaging: 1g
Price: $230
Updated: 2021/12/16

AK Scientific

Product number: W4127
Product name: 7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine
Packaging: 10g
Price: $404
Updated: 2021/12/16

Matrix Scientific

Product number: 070046
Product name: 7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidinehydrochloride
Purity: >95%
Packaging: 1g
Price: $785
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0105490
Product name: 7-BENZYL-4-CHLORO-5,6,7,8-TETRA-HYDRO-PYRIDO(3,4-D)PYRIMIDINE
Purity: 95.00%
Packaging: 1G
Price: $1866.48
Updated: 2021/12/16

Matrix Scientific

Product number: 070046
Product name: 7-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidinehydrochloride
Purity: >95%
Packaging: 5g
Price: $2145
Updated: 2021/12/16

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7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

62458-96-2

192869-80-0

7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidin-4(3H)-one (3.00 g, 12.4 mmol) was used as a raw material and dissolved in toluene (40 mL) at room temperature. To this solution, phosphorus trichloride (2.28 g, 14.9 mmol) and Hunig base (1.28 g, 9.92 mmol) were sequentially added, and the reaction system was subsequently heated to 100 °C and maintained for 30 min. After completion of the reaction, it was cooled to room temperature. The reaction mixture was quenched with 200 mL of saturated aqueous sodium bicarbonate and 200 mL of crushed ice and stirred for 1 hour at room temperature. Subsequently, extraction was performed with dichloromethane (100 mL x 4). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 3.32 g of 7-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine (69B) as a dark brown oil in about 100% yield. The product could be used in the next reaction without further purification.HPLC retention time: 0.95 min. Mass spectrum (MH+) m/z: 260.

References

[1] Patent: WO2005/42537, 2005, A1. Location in patent: Page/Page column 86
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 18, p. 5019 - 5024
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 1, p. 160 - 167
[4] Patent: WO2009/158396, 2009, A1. Location in patent: Page/Page column 67-68
[5] Patent: WO2005/66171, 2005, A1. Location in patent: Page/Page column 59-60

7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE 192869-80-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-04-30

Career Henan Chemical Co

Product: 7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE 192869-80-0
Price: US $6.60/KG
Min. Order: 1KG
Purity: 98%-99%
Supply Ability: 1kg-100kg
Release date: 2020-01-07

192869-80-0, 7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDERelated Search:

Tetryzoline 7-Benzyl-2,4-dichloro-5,6... 7-benzyl-4-chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE 7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE

7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE

7-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIDINE

7-benzyl-4-chloro-5

7-Benzyl-4-chloro-5,6,7,8-tetrahydro-quinazoline

Pyrido[3,4-d]pyriMidine,4-chloro-5,6,7,8-tetrahydro-7-(phenylMethyl)-

7-Benzyl-5,6,7,8-tetrahydro4-chloro-pyrido[3,4-D]pyriMidine

7-BENZYL-4-CHLORO-5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE HCL

7-Benzyl-4-chloro-5,6,7,8-tetrahydro-1,3,7-triazanaphthalene

7-benzyl-4-chloro-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine

7-BENZYL-5,6,7,8-TETRAHYDRO4-CHLORO-PYRIDO[3,4-D]PYRIMIDINE HYDROCHLORIDE ISO 9001：2015 REACH

4-Chloro-5,6,7,8-tetrahydro-7-(phenylmethyl)pyrido[3,4-d]pyrimidine

4-Chloro-5,6,7,8-tetrahydro-7-(benzyl)-pyrido[3,4-d]pyrimidine

192869-80-0

Heterocycle-Pyrimidine series

CHIRAL CHEMICALS