5-NAPHTHALEN-2-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID
- Product Name
- 5-NAPHTHALEN-2-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID
- CAS No.
- 164295-94-7
- Chemical Name
- 5-NAPHTHALEN-2-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID
- Synonyms
- GL-0334;EU-0099932;BB_SC-1405;Zinc04244828;5-Naphth-2-yl-1H-pyrazole-3-carboxylic acid;5-(2-naphthyl)-2H-pyrazole-3-carboxylic acid;3-(2-naphthyl)-1H-pyrazole-5-carboxylic acid;5-NAPHTHALEN-2-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID;3-naphthalen-2-yl-1H-pyrazole-5-carboxylic acid;5-(2-Naphthalenyl)-1H-pyrazole-3-carboxylic acid
- CBNumber
- CB3473872
- Molecular Formula
- C14H10N2O2
- Formula Weight
- 238.24
- MOL File
- 164295-94-7.mol
5-NAPHTHALEN-2-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID Property
- Boiling point:
- 558.8±38.0 °C(Predicted)
- Density
- 1.377±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.92±0.10(Predicted)
Safety
- Hazard Codes
- Xi
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B504313
- Product name
- 5-(Naphthalen-2-yl)-1H-pyrazole-3-carboxylicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR01769
- Product name
- 5-Naphth-2-yl-1H-pyrazole-3-carboxylicacid
- Packaging
- 50mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 4H21-1-G0
- Product name
- 5-Naphth-2-yl-1H-pyrazole-3-carboxylic acid
- Packaging
- 50mg
- Price
- $61
- Updated
- 2021/12/16
- Product number
- OR01769
- Product name
- 5-Naphth-2-yl-1H-pyrazole-3-carboxylicacid
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 4H21-1-G0
- Product name
- 5-Naphth-2-yl-1H-pyrazole-3-carboxylic acid
- Packaging
- 250mg
- Price
- $96
- Updated
- 2021/12/16
5-NAPHTHALEN-2-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
105356-61-4
164295-94-7
4.1.1.1 Synthesis of 5-(4-methylphenyl)-1H-pyrazole-3-carboxylic acid (1): 0.4 g of 4-(4-methylphenyl)-2,4-dioxobutanoic acid and 20 mL of glacial acetic acid were added to a 50 mL round bottom flask. Under stirring conditions, 280 μL (3 equivalents) of hydrazine monohydrate (N2H4-H2O) was added slowly and dropwise. Immediately after the dropwise addition of hydrazine, the solution changed to a light yellow color. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was poured into 50 mL of water and stirred overnight. The white precipitate was collected by filtration, dried in air and subsequently recrystallized by hexane/ethanol (ca. 9:1) solvent mixture to give 0.34 g of product in 87% yield.4.1.2.14 Synthesis of 5-(naphthalen-2-yl)-1H-pyrazole-3-carboxylic acid (14): 0.58 g of 4-(naphthalen-2-yl)-2,4-dioxobutyric acid was used as a starting material and following the same steps as above operation, 0.49 g of product was obtained in 82% yield. The product is a white solid with a melting point of 274-276°C (decomposition). Molecular formula: C14H10N2O2, molecular weight: 238.24. ESI-MS: calculated value [M+H]+: 239.08150, measured value: 239.08065. IR (ν, cm-1): 3206 (N-H stretching vibration), 1683 (C=O stretching vibration), 1501,1274. 1H NMR (200MHz, DMSO-d6): 3206, 1683, 1501,1274. DMSO-d6) δ (ppm): 7.23 (s, 1H), 7.50 (t, J=3.93 Hz, 2H), 7.89 (d, 7.95 Hz, 1H, overlapping bimodal peaks), 7.95 (d, J=8.42 Hz, 2H), 8.04 (d, J=8.42 Hz, 1H), 8.39 (s, 1H).13C NMR ( 50MHz, DMSO-d6) δ (ppm): 104.77,123.81,124.00,126.23,126.71,127.93,128.31,128.55,130.40,132.77,133.50,141.89,149.21,163.07.
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4649 - 4659
5-NAPHTHALEN-2-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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