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EOAI3402143

Product Name
EOAI3402143
CAS No.
1699750-95-2
Chemical Name
EOAI3402143
Synonyms
EOAI3402143;EOAI3402143 ，S6877;EOAI3402143Tosylate;EOAI3402143 (Deubiquitinase inhibitor G9;Inhibitor,Deubiquitinase,DUBs,inhibit,EOAI3402143,EOAI 3402143,EOAI-3402143;(E)-2-Cyano-3-(3,6-dichloropyridin-2-yl)-N-(1-(4-(2-morpholinoethoxy)phenyl)butyl)acrylamide;(2E)-2-Cyano-3-(3,6-dichloro-2-pyridinyl)-N-[1-[4-[2-(4-morpholinyl)ethoxy]phenyl]butyl]-2-propenamide;2-Propenamide, 2-cyano-3-(3,6-dichloro-2-pyridinyl)-N-[1-[4-[2-(4-morpholinyl)ethoxy]phenyl]butyl]-, (2E)-
CBNumber
CB34796649
Molecular Formula
C25H28Cl2N4O3
Formula Weight
503.42
MOL File
1699750-95-2.mol
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EOAI3402143 Property

Boiling point:
711.2±60.0 °C(Predicted)
Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:75.0(Max Conc. mg/mL);148.98(Max Conc. mM)
form 
Solid
pka
10.73±0.46(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0040552
Product name
EOAI3402143
Purity
99.52%
Packaging
5mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0040552
Product name
EOAI3402143
Purity
99.52%
Packaging
10mg
Price
$290
Updated
2021/12/16
ChemScene
Product number
CS-0040552
Product name
EOAI3402143
Purity
99.52%
Packaging
25mg
Price
$620
Updated
2021/12/16
ChemScene
Product number
CS-0040552
Product name
EOAI3402143
Purity
99.52%
Packaging
50mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0040552
Product name
EOAI3402143
Purity
99.52%
Packaging
100mg
Price
$1900
Updated
2021/12/16
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EOAI3402143 Chemical Properties,Usage,Production

Uses

EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits Usp9x/Usp24 and Usp5.

in vivo

To examine this potential, the effect of EOAI3402143 (G9) treatment is investigated on human MIAPACA2 tumor xenografts. Human MIAPACA2 cells are injected subcutaneously into NSG mice. Primary tumor development is monitored by caliper measurements, and once measurable, mice are separated into two groups and are treated with either vehicle control (PEG300/DMSO) or G9 at 15 mg/kg. Tumor growth, animal weight, behavior, and mobility are monitored during treatment. In parallel, murine 8041 tumors are also established and subjected to similar G9 treatment and tumor monitoring regimen as the human MIAPACA2 xenografts. Consistent with the in vitro findings, Usp9x inhibition results in the suppression of tumor growth in human tumor xenografts, but any significant effect on the growth of 8041 tumors xenografts is not observed, although the Usp9x activity is inhibited effectively by EOAI3402143 treatment in both human MIAPACA2 and mouse 8041 xenograft tumors[3].

References

[1] Potu H, et al. Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway. Oncotarget. 2014 Jul 30;5(14):5559-69. DOI:10.18632/oncotarget.2140
[2] Peterson LF, et al. Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. Blood. 2015 Jun 4;125(23):3588-97. DOI:10.1182/blood-2014-10-605584
[3] Pal A, et al. Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth. Neoplasia. 2018 Feb;20(2):152-164. DOI:10.1016/j.neo.2017.11.007

EOAI3402143 Preparation Products And Raw materials

Raw materials

Preparation Products

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EOAI3402143 Suppliers

China 47 United States 3 Global 50
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15724
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64
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1945
Advantage
55
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471;
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58

1699750-95-2, EOAI3402143Related Search:

Decyltrimethylammonium chloride

  • EOAI3402143
  • EOAI3402143 (Deubiquitinase inhibitor G9
  • 2-Propenamide, 2-cyano-3-(3,6-dichloro-2-pyridinyl)-N-[1-[4-[2-(4-morpholinyl)ethoxy]phenyl]butyl]-, (2E)-
  • (2E)-2-Cyano-3-(3,6-dichloro-2-pyridinyl)-N-[1-[4-[2-(4-morpholinyl)ethoxy]phenyl]butyl]-2-propenamide
  • EOAI3402143Tosylate
  • (E)-2-Cyano-3-(3,6-dichloropyridin-2-yl)-N-(1-(4-(2-morpholinoethoxy)phenyl)butyl)acrylamide
  • Inhibitor,Deubiquitinase,DUBs,inhibit,EOAI3402143,EOAI 3402143,EOAI-3402143
  • EOAI3402143 ，S6877
  • 1699750-95-2
  • C25H28Cl2N4O3