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Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)

Product Name
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)
CAS No.
2021249-10-3
Chemical Name
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)
Synonyms
Vilanterol-d4 Triphenylacetate;Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate);α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy-d4]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, triphenylacetate
CBNumber
CB34797732
Molecular Formula
C44H49Cl2NO7
Formula Weight
774.78
MOL File
2021249-10-3.mol
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Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Property

solubility 
DMF: soluble; DMSO: soluble; Methanol: soluble
form 
A solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30813
Product name
Vilanterol-d4 (triphenylacetate)
Packaging
500μg
Price
$303
Updated
2024/03/01
Cayman Chemical
Product number
30813
Product name
Vilanterol-d4 (triphenylacetate)
Packaging
1mg
Price
$576
Updated
2024/03/01
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Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Chemical Properties,Usage,Production

Description

Vilanterol-d4 is intended for use as an internal standard for the quantification of vilanterol by GC- or LC-MS. Vilanterol is a long-acting agonist of the β2-adrenergic receptor (β2-AR).1 It selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50 = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine in guinea pigs when administered via nebulization (EC50 = 30 μM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

References

1. Procopiou, P.A., Barrett, V.J., Bevan, N.J., et al. Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: An antedrug approach J. Med. Chem. 53(11),4522-4530(2010).

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Preparation Products And Raw materials

Raw materials

Preparation Products

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Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Suppliers

China 10 United States 3 Global 13
Guangzhou Dreampharm Biotechnology Co., Ltd.
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Cato Research Chemicals Inc.
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2021249-10-3, Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)Related Search:

Carbamic acid, N-[2-(2,2-dimethyl-4H-1,3-benzodioxin-5-yl)-2-oxoethyl]-, 1,1-dimethylethyl ester Benzaldehyde, 5-[(1R)-2-[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexyl]amino]-1-hydroxyethyl]-2-hydroxy- (1R)-2-[[6-[2-[(2,6-Dichlorobenzyl)oxy]ethoxy]hexyl]aMino]-1-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)ethanol Vilanterol Impurity 7 Triphenylacetate Vilanterol Trifenatate Vilanterol Impurity 6 Triphenylacetate Vilanterol Impurity 25 Vilanterol Impurity 23 Vilanterol Impurity 14 5-(2,2-diMethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one Vilanterol Impurity 3 Triphenylacetate

  • Vilanterol-d4 Triphenylacetate
  • Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)
  • α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy-d4]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, triphenylacetate
  • 2021249-10-3