10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile

Product Name: 10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile
CAS No.: 1309925-39-0
Chemical Name: 10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile
Synonyms: Tubulin inhibitor 8;Tubulin inhibitor 8, 10 mM in DMSO;10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile;10H-Phenoxazine-3-carbonitrile, 10-(4-methoxybenzoyl)-
CBNumber: CB34800467
Molecular Formula: C21H14N2O3
Formula Weight: 342.35
MOL File: 1309925-39-0.mol

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10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile Property

Melting point:: 184-185 °C
Boiling point:: 550.8±50.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
pka: -6.73±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile Chemical Properties,Usage,Production

Uses

Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM[1].

References

[1] Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63. DOI:10.1021/jm200436t

10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile Suppliers

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1309925-39-0, 10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrileRelated Search:

10-(4-methoxybenzoyl)-10h-phenoxazine-3-carbonitrile

Tubulin inhibitor 8

10H-Phenoxazine-3-carbonitrile, 10-(4-methoxybenzoyl)-

Tubulin inhibitor 8, 10 mM in DMSO

1309925-39-0