ChemicalBook > CAS DataBase List > AZD7507

AZD7507

Product Name
AZD7507
CAS No.
1041852-85-0
Chemical Name
AZD7507
Synonyms
AZD7507;CS-2850;AZD7507, 10 mM in DMSO;AZD7507; AZD-7507; AZD 7507;1041852-85-0;4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide;3-Cinnolinecarboxamide, 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-;AZD7507,AZD 7507,Inhibitor,AZD-7507,CSF-1R,CSF1R,CSF-1 receptor,c-Fms,inhibit,colony stimulating factor 1 receptor
CBNumber
CB34804162
Molecular Formula
C23H27FN6O3
Formula Weight
454.5
MOL File
1041852-85-0.mol
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AZD7507 Property

Boiling point:
680.7±65.0 °C(Predicted)
Density 
1.346±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
14.47±0.30(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0064524
Product name
AZD7507
Purity
99.45%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0064524
Product name
AZD7507
Purity
99.45%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0064524
Product name
AZD7507
Purity
99.45%
Packaging
25mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0064524
Product name
AZD7507
Purity
99.45%
Packaging
50mg
Price
$1750
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573134
Product name
AZD7507
Purity
>98%
Packaging
100mg
Price
$2245.7
Updated
2021/12/16
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AZD7507 Chemical Properties,Usage,Production

Uses

AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity.

in vivo

AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC50 is >20 μM[1]. AZD7507 significantly decreases the number of CD68+ macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells[2].

References

[1] Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6. DOI:10.1016/j.bmcl.2013.06.031
[2] Boulter L, et al. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Send to J Clin Invest. 2015 Mar 2;125(3):1269-85. DOI:10.1172/JCI76452

AZD7507 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD7507 Suppliers

CHINA 30 United States 7 Global 37
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Shanghai Changyu Medical Technology Co. Ltd.
Tel
+86-13301875428
Email
sales@changyuhe.com
Country
China
ProdList
311
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58

1041852-85-0, AZD7507Related Search:


  • AZD7507
  • AZD7507; AZD-7507; AZD 7507;1041852-85-0
  • CS-2850
  • 4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide
  • 3-Cinnolinecarboxamide, 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-
  • AZD7507,AZD 7507,Inhibitor,AZD-7507,CSF-1R,CSF1R,CSF-1 receptor,c-Fms,inhibit,colony stimulating factor 1 receptor
  • AZD7507, 10 mM in DMSO
  • 1041852-85-0
  • C23H27FN6O3