ChemicalBook > CAS DataBase List > AZD7507

AZD7507

Product Name
AZD7507
CAS No.
1041852-85-0
Chemical Name
AZD7507
Synonyms
AZD7507;CS-2850;AZD7507, 10 mM in DMSO;AZD7507; AZD-7507; AZD 7507;1041852-85-0;4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide;3-Cinnolinecarboxamide, 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-;AZD7507,AZD 7507,Inhibitor,AZD-7507,CSF-1R,CSF1R,CSF-1 receptor,c-Fms,inhibit,colony stimulating factor 1 receptor
CBNumber
CB34804162
Molecular Formula
C23H27FN6O3
Formula Weight
454.5
MOL File
1041852-85-0.mol
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AZD7507 Property

Boiling point:
680.7±65.0 °C(Predicted)
Density 
1.346±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
14.47±0.30(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0064524
Product name
AZD7507
Purity
99.45%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0064524
Product name
AZD7507
Purity
99.45%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0064524
Product name
AZD7507
Purity
99.45%
Packaging
25mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0064524
Product name
AZD7507
Purity
99.45%
Packaging
50mg
Price
$1750
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573134
Product name
AZD7507
Purity
>98%
Packaging
100mg
Price
$2245.7
Updated
2021/12/16
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AZD7507 Chemical Properties,Usage,Production

Uses

AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity.

in vivo

AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC50 is >20 μM[1]. AZD7507 significantly decreases the number of CD68+ macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells[2].

References

[1] Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6. DOI:10.1016/j.bmcl.2013.06.031
[2] Boulter L, et al. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Send to J Clin Invest. 2015 Mar 2;125(3):1269-85. DOI:10.1172/JCI76452

AZD7507 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD7507 Suppliers

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1041852-85-0, AZD7507Related Search:


  • AZD7507
  • AZD7507; AZD-7507; AZD 7507;1041852-85-0
  • CS-2850
  • 4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide
  • 3-Cinnolinecarboxamide, 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-
  • AZD7507,AZD 7507,Inhibitor,AZD-7507,CSF-1R,CSF1R,CSF-1 receptor,c-Fms,inhibit,colony stimulating factor 1 receptor
  • AZD7507, 10 mM in DMSO
  • 1041852-85-0
  • C23H27FN6O3