ChemicalBook > CAS DataBase List > N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide

N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide

Product Name: N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
CAS No.: 143655-70-3
Chemical Name: N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
Synonyms: Exatecan Intermediate 5;N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide;Acetamide, N,N'-(3-fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1,7-naphthalenediyl)bis- (9CI)
CBNumber: CB34804586
Molecular Formula: C15H17FN2O3
Formula Weight: 292.31
MOL File: 143655-70-3.mol

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N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide Property

Boiling point:: 596.8±50.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 13.55±0.40(Predicted)
form: Solid
color: Off-white to gray
InChI: InChI=1S/C15H17FN2O3/c1-7-10-4-5-12(17-8(2)19)15(21)14(10)13(6-11(7)16)18-9(3)20/h6,12H,4-5H2,1-3H3,(H,17,19)(H,18,20)
InChIKey: UNQLSBJKEGXCGH-UHFFFAOYSA-N
SMILES: C1(NC(=O)C)=C2C(CCC(NC(=O)C)C2=O)=C(C)C(F)=C1

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 0364DA
Product name: N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
Packaging: 100mg
Price: $1072
Updated: 2021/12/16

AK Scientific

Product number: 0364DA
Product name: N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
Packaging: 1g
Price: $3165
Updated: 2021/12/16

Crysdot

Product number: CD12189896
Product name: N,N’-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
Purity: 95%
Packaging: 100mg
Price: $986
Updated: 2021/12/16

Crysdot

Product number: CD12189896
Product name: N,N’-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide
Purity: 95%
Packaging: 250mg
Price: $1230
Updated: 2021/12/16

Chemenu

Product number: CM327830
Product name: N-(8-acetamido-6-fluoro-5-methyl-1-oxo-3,4-dihydro-2H-naphthalen-2-yl)acetamide
Purity: 95%+
Packaging: 1000g
Price: $27600
Updated: 2021/12/16

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N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide Chemical Properties,Usage,Production

Uses

Exatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs).

IC 50

Camptothecins

References

[1] Xu, et al. Preparation of exatecan intermediate and its application. China, CN115701419 A. 2023-02-10.
[2] Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. DOI:10.1111/j.1349-7006.1995.tb02468.x

N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide 143655-70-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

143655-70-3, N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamideRelated Search:

N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide

Acetamide, N,N'-(3-fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1,7-naphthalenediyl)bis- (9CI)

Exatecan Intermediate 5

143655-70-3