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2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-

Product Name
2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-
CAS No.
574759-62-9
Chemical Name
2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-
Synonyms
VAF347;4-(3-Chlorophenyl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine;2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-;inhibit,Inhibitor,Aryl Hydrocarbon Receptor,VAF 347,AhR,VAF347,VAF-347
CBNumber
CB34808812
Molecular Formula
C17H11ClF3N3
Formula Weight
349.74
MOL File
574759-62-9.mol
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2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]- Property

Boiling point:
477.8±55.0 °C(Predicted)
Density 
1.384±0.06 g/cm3(Predicted)
solubility 
DMF: 5 mg/ml; DMSO: 1 mg/ml; Ethanol: Slightly soluble
form 
A solid
pka
2.11±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0113926
Product name
VAF347
Purity
99.85%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0113926
Product name
VAF347
Purity
99.85%
Packaging
50mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0113926
Product name
VAF347
Purity
99.85%
Packaging
100mg
Price
$750
Updated
2021/12/16
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2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]- Chemical Properties,Usage,Production

Description

VAF347 is an agonist of the aryl hydrocarbon receptor (AhR).1 It binds to AhR in a radioligand binding assay using guinea pig hepatic cytosol and induces mRNA expression of the AhR target gene CYP1A1 in isolated human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 50 nM. VAF347 (20 μM) inhibits differentiation of HL-60 leukemia cells induced by 1,25-dihydroxy vitamin D3 (calcitriol; ) and promotes differentiation of HL-60 cells induced by all-trans retinoic acid .2 It decreases serum IgE levels and lung and bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-induced mouse model of allergic inflammation when administered at a dose of 30 mg/kg.3 VAF347 (30 mg/kg) also prevents retinal capillary degeneration in a mouse model of diabetic retinopathy induced by streptozotocin (STZ; ).4

References

1. Lawrence, B.P., Denison, M.S., Novak, H., et al. Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound Int. J. Mol. Sci. 112(4),1158-1165(2008).
2. Ibabao, C.N., Bunaciu, R.P., Schaefer, D.M.W., et al. The AhR agonist VAF347 augments retinoic acid-induced differentiation in leukemia cells FEBS Open Bio. 5,308-318(2015).
3. Ettmayer, P., Mayer, P., Kalthoff, F., et al. A novel low molecular weight inhibitor of dendritic cells and B cells blocks allergic inflammation Am. J. Respir. Crit. Care Med. 173(6),599-606(2006).
4. Zapadka, T.E., Lindstrom, S.I., Batoki, J.C., et al. Aryl hydrocarbon receptor agonist VAF347 impedes retinal pathogenesis in diabetic mice Int. J. Mol. Sci. 22(9),4335(2021).

2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]- Suppliers

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574759-62-9, 2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-Related Search:


  • 2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-
  • 4-(3-Chlorophenyl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine
  • VAF347
  • inhibit,Inhibitor,Aryl Hydrocarbon Receptor,VAF 347,AhR,VAF347,VAF-347
  • 574759-62-9