2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-

Product Name: 2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-
CAS No.: 574759-62-9
Chemical Name: 2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-
Synonyms: VAF347;VAF347, 10 mM in DMSO;4-(3-Chlorophenyl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine;2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-;inhibit,Inhibitor,Aryl Hydrocarbon Receptor,VAF 347,AhR,VAF347,VAF-347
CBNumber: CB34808812
Molecular Formula: C17H11ClF3N3
Formula Weight: 349.74
MOL File: 574759-62-9.mol

More

Less

2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]- Property

Boiling point:: 477.8±55.0 °C(Predicted)
Density: 1.384±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 5 mg/ml; DMSO: 1 mg/ml; Ethanol: Slightly soluble
form: A solid
pka: 2.11±0.10(Predicted)
color: White to off-white
InChIKey: XTKUZTBZRIJTFR-UHFFFAOYSA-N
SMILES: C1=CC(=CC(=C1)Cl)C2=NC(=NC=C2)NC3=CC=C(C=C3)C(F)(F)F

More

Less

Safety

WGK Germany: WGK 2
Storage Class: 11 - Combustible Solids

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 182690
Product name: AhR Agonist V, VAF347
Purity: The AhR Agonist V, VAF347 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.
Packaging: 10 mg
Price: $210
Updated: 2026/04/30

Cayman Chemical

Product number: 37328
Product name: VAF347
Purity: ≥98%
Packaging: 1mg
Price: $29
Updated: 2026/04/30

Cayman Chemical

Product number: 37328
Product name: VAF347
Purity: ≥98%
Packaging: 5mg
Price: $113
Updated: 2026/04/30

Cayman Chemical

Product number: 37328
Product name: VAF347
Purity: ≥98%
Packaging: 10mg
Price: $197
Updated: 2026/04/30

Cayman Chemical

Product number: 37328
Product name: VAF347
Purity: ≥98%
Packaging: 25mg
Price: $422
Updated: 2026/04/30

More

Less

2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]- Chemical Properties,Usage,Production

Description

VAF347 is an agonist of the aryl hydrocarbon receptor (AhR).¹ It binds to AhR in a radioligand binding assay using guinea pig hepatic cytosol and induces mRNA expression of the AhR target gene CYP1A1 in isolated human peripheral blood mononuclear cells (PBMCs) when used at a concentration of 50 nM. VAF347 (20 μM) inhibits differentiation of HL-60 leukemia cells induced by 1,25-dihydroxy vitamin D₃ (calcitriol; ) and promotes differentiation of HL-60 cells induced by all-trans retinoic acid .² It decreases serum IgE levels and lung and bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-induced mouse model of allergic inflammation when administered at a dose of 30 mg/kg.³ VAF347 (30 mg/kg) also prevents retinal capillary degeneration in a mouse model of diabetic retinopathy induced by streptozotocin (STZ; ).⁴

Uses

VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects[1].

in vivo

In wild-type mice, VAF347 treatment leads to a strong reduction of total serum IgE levels compared with vehicle-treated animals. IL-5 levels in the bronchoalveolar fluid are inhibited to a comparable degree. AhR-deficient mice are resistant to the VAF347's ability to block allergic lung inflammation in vivo^[2].

References

1. Lawrence, B.P., Denison, M.S., Novak, H., et al. Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound Int. J. Mol. Sci. 112(4),1158-1165(2008).
2. Ibabao, C.N., Bunaciu, R.P., Schaefer, D.M.W., et al. The AhR agonist VAF347 augments retinoic acid-induced differentiation in leukemia cells FEBS Open Bio. 5,308-318(2015).
3. Ettmayer, P., Mayer, P., Kalthoff, F., et al. A novel low molecular weight inhibitor of dendritic cells and B cells blocks allergic inflammation Am. J. Respir. Crit. Care Med. 173(6),599-606(2006).
4. Zapadka, T.E., Lindstrom, S.I., Batoki, J.C., et al. Aryl hydrocarbon receptor agonist VAF347 impedes retinal pathogenesis in diabetic mice Int. J. Mol. Sci. 22(9),4335(2021).

2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]- Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]- Suppliers

China 32 United States 3 Global 35

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89689
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29661
Advantage: 68

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 1143
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24960
Advantage: 58

574759-62-9, 2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-Related Search:

2-PYRIMIDINAMINE, 4-(3-CHLOROPHENYL)-N-[4-(TRIFLUOROMETHYL)PHENYL]-

4-(3-Chlorophenyl)-N-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine

VAF347

inhibit,Inhibitor,Aryl Hydrocarbon Receptor,VAF 347,AhR,VAF347,VAF-347

VAF347, 10 mM in DMSO

574759-62-9