ISOCYCLOCITRAL Property

Odor

at 100.00 %. green aldehydic earthy woody herbal leaf

Odor Type

green

LogP

2.870

EPA Substance Registry System

Isocyclocitral (1335-66-6)

Safety

Toxicity

The acute oral LD₅₀ value in rats was reported to be 4.5 ml/kg (4.16-4.86 ml/kg) (Levenstein, 1973a). The acute dermal LD₅₀ value was reported to be > 5 ml/kg in the rabbit(Levenstein, 1973b).

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

ISOCYCLOCITRAL Chemical Properties,Usage,Production

Description

Reported in several of the NAS food additive surveys, but no technical effect (food functionality) given.

Chemical Properties

iso-CYCLOCITRAL is a colorless liquid. Insoluble in water, soluble in alcohol and oils. Sp.Gr. 0.93. Powerful, and diffusive, foliage-green, "dark"-weedy and dry odor, sometimes described as "Flower-shop odor". The earthy and wet-green notes are quite natural in high dilution and resemble the odor of stems from plants and flowers fresh from the soil.

Occurrence

Has apparently not been reported to occur in nature

Uses

iso-CYCLOCITRAL finds use in perfume compositions where it blends excellently with Oakmoss products (compensates for sweetness and lifts the topnote), with Ionones (freshness), Geranium and Galbanum (enhances the green and “vegetable” notes), etc.

Preparation

By a Diels-Alder-type condensation of 2-methyl-l,3-pentadiene with crotonaldehyde(Bedoukian, 1967).
By a DieIs-Alder type condensation of 2-Methyl-2,4-pentadiene and Crotonaldehyde. The reaction product is a mixture of isomers commercially called iso-Cyclocitral (after rectification).

Definition

ChEBI: Isocyclocitral is an organooxygen compound.