ChemicalBook > CAS DataBase List > AZD 5718)
AZD 5718)
- Product Name
- AZD 5718)
- CAS No.
- 2041075-86-7
- Chemical Name
- AZD 5718)
- Synonyms
- Atuliflapon;Atuliflapon (AZD5718);Atuliflapon, 10 mM in DMSO;Inhibitor,inhibit,FLAP,AZD-5718,AZD 5718,artery,Atuliflapon,disease,Coronary,5-LO activating protein;(1R,2R)-2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-{4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-3-yl}cyclohexane-1-carboxamide;(1R,2R)-2-(4-(5-Methyl-1H-pyrazol-3-yl)benzoyl)-N-(4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3-yl)cyclohexane-1-carboxamide;Cyclohexanecarboxamide, 2-[4-(5-methyl-1H-pyrazol-3-yl)benzoyl]-N-(4,5,6,7-tetrahydro-4-oxopyrazolo[1,5-a]pyrazin-3-yl)-, (1R,2R)-
- CBNumber
- CB34844513
- Molecular Formula
- C24H26N6O3
- Formula Weight
- 446.5
- MOL File
- 2041075-86-7.mol
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AZD 5718) Property
- Boiling point:
- 851.1±65.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- solubility
- DMSO : 125 mg/mL (279.96 mM; Need ultrasonic)
- form
- Solid
- pka
- 13.12±0.10(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- DC22009
- Product name
- AZD5718
- Purity
- >98%
- Packaging
- 100mg
- Price
- $750
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC22009
- Product name
- AZD5718
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1400
- Updated
- 2021/12/16
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AZD 5718) Chemical Properties,Usage,Production
Uses
Atuliflapon (AZD5718) is an orally active inhibitor of FLAP (5Lipoxygenase activating protein), with an IC50 of 2 nM. Atuliflapon is used in the study for coronary artery disease[1].
in vivo
Atuliflapon exhibits t1/2 of 0.45 h and 2.1 h in rat and dog by iv injection, respectively[1].
Atuliflapon shows no inhibition of 5-LO pathway activity in rodent blood[1].
References
[1] Daniel Pettersen, et al. Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease. J Med Chem. 2019 May 9;62(9):4312-4324. DOI:10.1021/acs.jmedchem.8b02004
AZD 5718) Preparation Products And Raw materials
Raw materials
Preparation Products
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