BMS-962212 (BMS962212)

Product Name: BMS-962212 (BMS962212)
CAS No.: 1430114-34-3
Chemical Name: BMS-962212 (BMS962212)
Synonyms: BMS96221;BMS-962212 (BMS962212);4-(2-(3-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-ca rboxamido)benzoic acid;(S,E)-4-(2-(3-(3-Chloro-2-fluoro-6-(1H-tetrazol-1- yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)- 1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid;Benzoic acid, 4-[[[(1S)-2-[(2E)-3-[3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl]-1-oxo-2-propen-1-yl]-1,2,3,4-tetrahydro-5-(4-methyl-2-oxo-1-piperazinyl)-1-isoquinolinyl]carbonyl]amino]-
CBNumber: CB34844573
Molecular Formula: C32H28ClFN8O5
Formula Weight: 659.07
MOL File: 1430114-34-3.mol

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BMS-962212 (BMS962212) Property

Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 4.27±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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BMS-962212 (BMS962212) Chemical Properties,Usage,Production

Uses

BMS-962212 is a direct, reversible, selective factor XIa (FXIa) inhibitor . BMS-962212 is well tolerated, with fast onset of pharmacodynamic (PD) responses and rapid elimination. BMS-962212 increases exposure dependently in activated partial thromboplastin time, and decreases exposure dependently in FXI clotting activity[1].

References

[1] Perera V, et al. First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS-962212, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese and Japanese healthy subjects. Br J Clin Pharmacol. 2018 May;84(5):8 DOI:10.1111/bcp.13520

BMS-962212 (BMS962212) Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-962212 (BMS962212) Suppliers

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1430114-34-3, BMS-962212 (BMS962212)Related Search:

BMS-962212 (BMS962212)

Benzoic acid, 4-[[[(1S)-2-[(2E)-3-[3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl]-1-oxo-2-propen-1-yl]-1,2,3,4-tetrahydro-5-(4-methyl-2-oxo-1-piperazinyl)-1-isoquinolinyl]carbonyl]amino]-

(S,E)-4-(2-(3-(3-Chloro-2-fluoro-6-(1H-tetrazol-1- yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)- 1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid

BMS96221

4-(2-(3-(3-Chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)acryloyl)-5-(4-methyl-2-oxopiperazin-1-yl)-1,2,3,4-tetrahydroisoquinoline-1-ca rboxamido)benzoic acid

1430114-34-3

C32H28ClFN8O5