dBET57

Product Name: dBET57
CAS No.: 1883863-52-2
Chemical Name: dBET57
Synonyms: dBET57;dBET57 ，S0137;Dbet57, 10 mM in DMSO;DBET57;DBET 57;DBET-57;inhibit,Dbet-57,dBET 57,Inhibitor,PROTACs,Dbet57,Epigenetic Reader Domain;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide;2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide;(6S)-4-(4-Chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trimethyl-, (6S)-
CBNumber: CB34844694
Molecular Formula: C34H31ClN8O5S
Formula Weight: 699.18
MOL File: 1883863-52-2.mol

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dBET57 Property

Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO: soluble
form: A solid
pka: 10.74±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0086541
Product name: dBET57
Purity: 99.81%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0086541
Product name: dBET57
Purity: 99.81%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0086541
Product name: dBET57
Purity: 99.81%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0086541
Product name: dBET57
Purity: 99.81%
Packaging: 100mg
Price: $850
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573445
Product name: dBET57
Packaging: 100mg
Price: $1283.5
Updated: 2021/12/16

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dBET57 Chemical Properties,Usage,Production

Uses

dBET57 is a BRD4 selective degrader.

in vivo

dBET57 (7.5 mg/kg, intraperitoneal injection, once daily, 2 weeks) has antitumor activity in the SK-NBE(2) xenograft mouse model^[1].

Animal Model:	SK-NBE(2) xenograft mouse model^[1]
Dosage:	7.5 mg/kg, daily, 2 weeks
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced tumor volume, decreased the proportion of ki-67 positive cells, increased the proportion of caspase3, had no obvious organ toxicity, and downregulated the level of ZMYND8.

IC 50

BRD4 (BD1): 500 nM (DC₅₀)

dBET57 Preparation Products And Raw materials

Raw materials

Preparation Products

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dBET57 Suppliers

China 50 United States 5 Global 55

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777;
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15724
Advantage: 64

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9531
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1623
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

1883863-52-2, dBET57Related Search:

dBET57

DBET57;DBET 57;DBET-57

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trimethyl-, (6S)-

inhibit,Dbet-57,dBET 57,Inhibitor,PROTACs,Dbet57,Epigenetic Reader Domain

2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide

2-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)acetamide

Dbet57, 10 mM in DMSO

dBET57 ，S0137

(6S)-4-(4-Chlorophenyl)-N-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

1883863-52-2

C34H31ClN8O5S