GB 1107)

Product Name: GB 1107)
CAS No.: 1978336-61-6
Chemical Name: GB 1107)
Synonyms: GB 1107);GB1107 (GB-1107;GB1107, 10 mM in DMSO;3,4-Dichlorophenyl 3-deoxy-1-thio-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-α-D-galactopyranoside;α-D-Galactopyranoside, 3,4-dichlorophenyl 3-deoxy-1-thio-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-;(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol
CBNumber: CB34844795
Molecular Formula: C20H16Cl2F3N3O4S
Formula Weight: 522.32
MOL File: 1978336-61-6.mol

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GB 1107) Property

Boiling point:: 740.1±70.0 °C(Predicted)
Density: 1.73±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C,protect from light
solubility: DMSO:50.0(Max Conc. mg/mL);95.73(Max Conc. mM)
form: Solid
pka: 12.48±0.70(Predicted)
color: White to off-white
InChIKey: CSGJIUAIYDKFPC-XOZWYLPJNA-N
SMILES: O[C@H]1[C@H](O[C@H](CO)[C@H](O)[C@@H]1N1N=NC(C2C=C(F)C(F)=C(F)C=2)=C1)SC1C=CC(Cl)=C(Cl)C=1 |&1:1,2,4,7,9,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0084978
Product name: GB1107
Purity: 99.73%
Packaging: 5mg
Price: $157
Updated: 2021/12/16

ChemScene

Product number: CS-0084978
Product name: GB1107
Purity: 99.73%
Packaging: 10mg
Price: $266
Updated: 2021/12/16

ChemScene

Product number: CS-0084978
Product name: GB1107
Purity: 99.73%
Packaging: 25mg
Price: $564
Updated: 2021/12/16

ChemScene

Product number: CS-0084978
Product name: GB1107
Purity: 99.73%
Packaging: 50mg
Price: $962
Updated: 2021/12/16

ChemScene

Product number: CS-0084978
Product name: GB1107
Purity: 99.73%
Packaging: 100mg
Price: $1665
Updated: 2021/12/16

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GB 1107) Chemical Properties,Usage,Production

Description

GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.

Uses

GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model[1].

in vivo

Oral administration of a novel small molecule galectin-3 inhibitor GB1107 reduced human and mouse lung adenocarcinoma growth and blocked metastasis in the syngeneic model. Treatment with GB1107 increased tumor M1 macrophage polarization and CD8+ T-cell infiltration. Moreover, GB1107 potentiated the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFNγ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules._x000D_ _x000D_ Reference: Cancer Res. 2019 Apr 1;79(7):1480-1492. https://pubmed.ncbi.nlm.nih.gov/30674531/

target

GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3.

IC 50

Galectin-3

References

[1] Vuong L, et al. An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. Cancer Res. 2019 Jan 23. pii: canres.2244.2018. DOI:10.1158/0008-5472.CAN-18-2244

GB 1107) Preparation Products And Raw materials

Raw materials

Preparation Products

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GB 1107) Suppliers

China 38 United States 3 Global 41

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 2998
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
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1978336-61-6, GB 1107)Related Search:

GB 1107)

GB1107 (GB-1107

(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol

α-D-Galactopyranoside, 3,4-dichlorophenyl 3-deoxy-1-thio-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-

GB1107, 10 mM in DMSO

3,4-Dichlorophenyl 3-deoxy-1-thio-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-α-D-galactopyranoside

1978336-61-6