GB 1107)
- Product Name
- GB 1107)
- CAS No.
- 1978336-61-6
- Chemical Name
- GB 1107)
- Synonyms
- GB 1107);GB1107 (GB-1107;GB1107, 10 mM in DMSO;α-D-Galactopyranoside, 3,4-dichlorophenyl 3-deoxy-1-thio-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-;(2R,3R,4S,5R,6R)-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(3,4,5-trifluorophenyl)triazol-1-yl]oxane-3,5-diol
- CBNumber
- CB34844795
- Molecular Formula
- C20H16Cl2F3N3O4S
- Formula Weight
- 522.32
- MOL File
- 1978336-61-6.mol
GB 1107) Property
- Boiling point:
- 740.1±70.0 °C(Predicted)
- Density
- 1.73±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C,protect from light
- solubility
- DMSO:50.0(Max Conc. mg/mL);95.73(Max Conc. mM)
- form
- Solid
- pka
- 12.48±0.70(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- CS-0084978
- Product name
- GB1107
- Purity
- 99.73%
- Packaging
- 5mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- CS-0084978
- Product name
- GB1107
- Purity
- 99.73%
- Packaging
- 10mg
- Price
- $266
- Updated
- 2021/12/16
- Product number
- CS-0084978
- Product name
- GB1107
- Purity
- 99.73%
- Packaging
- 25mg
- Price
- $564
- Updated
- 2021/12/16
- Product number
- CS-0084978
- Product name
- GB1107
- Purity
- 99.73%
- Packaging
- 50mg
- Price
- $962
- Updated
- 2021/12/16
- Product number
- CS-0084978
- Product name
- GB1107
- Purity
- 99.73%
- Packaging
- 100mg
- Price
- $1665
- Updated
- 2021/12/16
GB 1107) Chemical Properties,Usage,Production
Description
GB1107 is a potent, selective, orally active galectin-3 inhibitor with Kd of 37 nM. GB1107 Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.
in vivo
Oral administration of a novel small molecule galectin-3 inhibitor GB1107 reduced human and mouse lung adenocarcinoma growth and blocked metastasis in the syngeneic model. Treatment with GB1107 increased tumor M1 macrophage polarization and CD8+ T-cell infiltration. Moreover, GB1107 potentiated the effects of a PD-L1 immune checkpoint inhibitor to increase expression of cytotoxic (IFNγ, granzyme B, perforin-1, Fas ligand) and apoptotic (cleaved caspase-3) effector molecules._x000D_ _x000D_ Reference: Cancer Res. 2019 Apr 1;79(7):1480-1492. https://pubmed.ncbi.nlm.nih.gov/30674531/
target
GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3.
GB 1107) Preparation Products And Raw materials
Raw materials
Preparation Products
GB 1107) Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52924
- Advantage
- 58