diSulfo-Cyanine3 hydrazide
- Product Name
- diSulfo-Cyanine3 hydrazide
- CAS No.
- 2144762-62-7
- Chemical Name
- diSulfo-Cyanine3 hydrazide
- Synonyms
- Sulfo-Cy3 hydrazide;diSulfo-Cy3 hydrazide;Sulfo-Cyanine3 hydrazide;diSulfo-Cyanine3 hydrazide
- CBNumber
- CB34849442
- Molecular Formula
- C30H38N4O7S2
- Formula Weight
- 630.78
- MOL File
- 2144762-62-7.mol
diSulfo-Cyanine3 hydrazide Property
- solubility
- soluble in water, DMF, DMSO
- Appearance
- dark red solid
diSulfo-Cyanine3 hydrazide Chemical Properties,Usage,Production
Description
sulfo-Cyanine3 is a sulfated derivative of Cyanine3 dye, well soluble in water because of two negatively charged sulfo groups in its structure. By its spectral characteristics, this yellow-orange fluorescent dye is an analog of Cy™3.
Hydrazides efficiently react with aldehydes and ketones resulting in hydrazones, so this compound can be used for conjugation with carbonyl derivatives of biomolecules.
The reaction runs in aqueous conditions, which is important when working with antibodies and proteins. Cys-diol groups in sugars in glycosylated proteins and antibodies can be oxidized into dialdehydes, and cysteine in proteins can be converted with enzymes to formyl glycerol (i. e. reactive groups for conjugation with sulfo-Cyanine3 hydrazide). Carboxyl groups of aspartic and glutamic acids in proteins and peptides can be also conjugated with sulfo-Cyanine3 hydrazide in the presence of activating agents: carbodiimide (EDAC) or methyl morpholine (DMTMM) derivatives.
Uses
Sulfo-Cy3 hydrazide is a Cyanine 3 (Cy3) (HY-D0822) dye derivative with hydrazine functionality. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy3 is a fluorescent dye with a fluorescence spectrum typically in the green to orange wavelength range. The hydrazide group of Sulfo-Cy3 hydrazide can form hydrazinone coupling with molecules containing aldehydes or ketones to form covalent bonds. Therefore, Cy3 azide plus can bind to biomolecules such as proteins and antibodies to track their location and dynamic changes in biological samples.
Abs/Em Maxima
548/563 nm
Fluoresene quantum yield
0.1
Extinction Coefficient
162000
CF260
0.03
CF280
0.06
diSulfo-Cyanine3 hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from diSulfo-Cyanine3 hydrazide manufacturers
- Product
- diSulfo-Cy3 hydrazide 2144762-62-7
- Price
- US $0.00/mg
- Min. Order
- 25mg
- Purity
- >95.00%
- Supply Ability
- 25mg
- Release date
- 2024-03-29