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TRi-1

Product Name
TRi-1
CAS No.
246020-68-8
Chemical Name
TRi-1
Synonyms
TRi-1;TRi-1, 10 mM in DMSO;TRi-1(TXNRD1 inhibitor 1);Pyridine, 2-[(4-chlorophenyl)sulfonyl]-6-methoxy-3-nitro-;antitumor,inhibit,TRi 1,Inhibitor,FaDu,thioredoxin reductase 1,glutathione,TRi-1,TRi1,TXNRD1
CBNumber
CB34866452
Molecular Formula
C12H9ClN2O5S
Formula Weight
328.73
MOL File
246020-68-8.mol
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TRi-1 Property

Boiling point:
533.2±50.0 °C(Predicted)
Density 
1.502±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO : 62.5 mg/mL (190.13 mM; Need ultrasonic)
form 
Solid
pka
-8.51±0.29(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb573467
Product name
TRi-1 (TXNRD1 inhibitor 1)
Purity
>98%
Packaging
100mg
Price
$838.1
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573467
Product name
TRi-1 (TXNRD1 inhibitor 1)
Purity
>98%
Packaging
250mg
Price
$1431.4
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573467
Product name
TRi-1 (TXNRD1 inhibitor 1)
Purity
>98%
Packaging
1g
Price
$2691.1
Updated
2021/12/16
DC Chemicals
Product number
DC22309
Product name
TRi-1(TXNRD1inhibitor1)
Purity
>98%
Packaging
250mg
Price
$950
Updated
2021/12/16
DC Chemicals
Product number
DC22309
Product name
TRi-1(TXNRD1inhibitor1)
Purity
>98%
Packaging
100mg
Price
$550
Updated
2021/12/16
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TRi-1 Chemical Properties,Usage,Production

Uses

TRi-1 is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy[1].

in vivo

TRi-1 (10 mg/kg; i.v.; twice a day for 4 days or 5 mg/kg; i.p.; twice a week for 3 weeks) impaires growth and viability of human tumor xenografts and syngeneic mouse tumors[1].

Animal Model:SCID mice bearing established human FaDu cell xenografts[1]
Dosage:10 mg/kg
Administration:Intravenous injection, twice a day for 4 days
Result:Resulted in decreased tumor growth compared to vehicle controls within four days with no signs of overt toxicity or changes in mouse weight relative to vehicle control.
Animal Model:PyMT-MMTV mice that spontaneously develop malignant breast cancer tumors[1]
Dosage:5 mg/kg
Administration:Intraperitoneal injection, twice a week for 3 weeks
Result:Impaired tumor growth, significantly reduced tumor volumes.

References

[1] Stafford WC, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444. DOI:10.1126/scitranslmed.aaf7444

TRi-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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TRi-1 Suppliers

China 42 United States 5 Global 47
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16075
Advantage
64
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
984
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Heze Development Zone chuangli Chemical Co., Ltd.
Tel
0530-+86-530-529 6766，+86-15666160102 15666160102
Fax
0530-529 6766
Email
info@chuangli-chem.com
Country
China
ProdList
836
Advantage
55
Beijing OKA biological technology co., LTD
Tel
010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
10063
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58

246020-68-8, TRi-1Related Search:


  • TRi-1
  • TRi-1(TXNRD1 inhibitor 1)
  • antitumor,inhibit,TRi 1,Inhibitor,FaDu,thioredoxin reductase 1,glutathione,TRi-1,TRi1,TXNRD1
  • Pyridine, 2-[(4-chlorophenyl)sulfonyl]-6-methoxy-3-nitro-
  • TRi-1, 10 mM in DMSO
  • 246020-68-8