3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER
- Product Name
- 3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER
- CAS No.
- 70163-98-3
- Chemical Name
- 3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER
- Synonyms
- RARECHEM AL BF 0031;Methyl 3-fluorosalicylate;3-Fluorosalicylic acid methyl ester;3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER;Benzoic acid, 3-fluoro-2-hydroxy-, methyl ester
- CBNumber
- CB3488416
- Molecular Formula
- C8H7FO3
- Formula Weight
- 170.14
- MOL File
- 70163-98-3.mol
3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER Property
- Melting point:
- 46-47 °C
- Boiling point:
- 211.7±25.0 °C(Predicted)
- Density
- 1.309±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.50±0.10(Predicted)
- form
- solid
- color
- Off-white
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M223363
- Product name
- Methyl3-Fluoro-2-hydroxybenzoate
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 2629-3-47
- Product name
- Methyl 3-fluoro-2-hydroxybenzoate
- Packaging
- 5G
- Price
- $815
- Updated
- 2021/12/16
- Product number
- HCH0044502
- Product name
- 3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- Z1814
- Product name
- Methyl3-fluoro-2-hydroxybenzoate
- Packaging
- 10g
- Price
- $1214
- Updated
- 2021/12/16
- Product number
- 2629-3-47
- Product name
- Methyl 3-fluoro-2-hydroxybenzoate
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
455-68-5
70163-98-3
General procedure for the synthesis of methyl 3-fluoro-2-hydroxy-benzoate from methyl 3-fluorobenzoate: Ru(MesCO2)(L) (p-cymene) [L is 2,2'-pyridine or 4,4'-dibromo bipyridine] (2.5 mol%), oxidizing agent (2.0 eq.) and methyl 3-fluorobenzoate (1.0 eq.) were added to a sealed tube. Subsequently, a solvent mixture of trifluoroacetic acid (TFA) and trifluoroacetic anhydride (TFAA) in the ratio of 0.6 mL:0.4 was added. The reaction mixture was placed in an oil bath preheated to 110 °C with continuous stirring until the reaction was completed, and the reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was quenched by addition of ice water and extracted with dichloromethane. The organic layer was dried with anhydrous sodium sulfate (Na2SO4) and subsequently concentrated by rotary evaporation. Finally, the residue was purified by silica gel column chromatography to afford the target product methyl 3-fluoro-2-hydroxy-benzoate.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 38, p. 3743 - 3746
3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER manufacturers
- Product
- 3-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER 70163-98-3
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2024-08-05