2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide

Product Name: 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
CAS No.: 304481-72-9
Chemical Name: 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
Synonyms: WQ-2101;PKUMDL WQ 2101;PKUMDL WQ 2101,PKUMDLWQ2101;PKUMDL-WQ-2101 >=98% (HPLC);2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide;(E)-2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide;Benzoic acid, 2,4-dihydroxy-, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide
CBNumber: CB34902677
Molecular Formula: C14H11N3O6
Formula Weight: 317.25
MOL File: 304481-72-9.mol

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2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1970
Product name: PKUMDL-WQ-2101
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $102.06
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1970
Product name: PKUMDL-WQ-2101
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $218
Updated: 2025/07/31

Tocris

Product number: 6580
Product name: PKUMDLWQ2101
Purity: ≥98%(HPLC)
Packaging: 25
Price: $275
Updated: 2021/12/16

Tocris

Product number: 6580
Product name: PKUMDLWQ2101
Purity: ≥98%(HPLC)
Packaging: 5
Price: $71
Updated: 2021/12/16

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2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide Chemical Properties,Usage,Production

Uses

PKUMDL-WQ-2101 is a non-NAD+-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity[1].

Biological Activity

PKUMDL-WQ-2101 is a potent and selective non-NAD+-competing allosteric inhibitor of phosphoglycerate dehydrogenase (PHGDH) th at selectively inhibits serine synthesis in cancer cells. PKUMDL-WQ-2101 binds to allosteric site I, which is located close to active site. PKUMDL-WQ-2101 inhibits tumor growth of MDA-MB-468 xenografts in mice.

in vivo

PKUMDL-WQ-2101 (5-20 mg/kg; i.p; daily; for 30 days) exhibits substantial inhibitory effects on MDA-MB-468 xenografts^[1].

Animal Model:	NOD.CB17 Scid/J mice injected with MDA-MB-468 cells^[1]
Dosage:	5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	i.p; daily; for 30 days
Result:	Exhibited substantial inhibitory effects on MDA-MB-468 xenografts.

storage

Store at -20°C

References

[1] Qian Wang, et al. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. Cell Chem Biol. 2017 Jan 19;24(1):55-65. DOI:10.1016/j.chembiol.2016.11.013

2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide Suppliers

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304481-72-9, 2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazideRelated Search:

PKUMDL WQ 2101

Benzoic acid, 2,4-dihydroxy-, 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide

PKUMDL-WQ-2101 >=98% (HPLC)

PKUMDL WQ 2101,PKUMDLWQ2101

WQ-2101

2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide

(E)-2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide

304481-72-9