2-Methyl-5-(2-thienyl)-3-furancarboxylic acid

Product Name: 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
CAS No.: 651005-90-2
Chemical Name: 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
Synonyms: Jedi2;Compound Fr13138;Jedi2, 10 mM in DMSO;2-Methyl-5-(2-thienyl)-3-furancarboxylic acid;3-Furancarboxylic acid, 2-methyl-5-(2-thienyl)-
CBNumber: CB34902758
Molecular Formula: C10H8O3S
Formula Weight: 208.23
MOL File: 651005-90-2.mol

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2-Methyl-5-(2-thienyl)-3-furancarboxylic acid Property

Boiling point:: 356.9±42.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: powder
pka: 4.38±0.26(Predicted)
color: White

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Safety

HS Code: 2932190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2532
Product name: Jedi2
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $99.75
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2532
Product name: Jedi2
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $406
Updated: 2025/07/31

Sigma-Aldrich

Product number: PH017256
Product name: 2-Methyl-5-(2-thienyl)-3-furoic acid
Purity: AldrichCPR
Packaging: 500MG
Price: $99.7
Updated: 2023/06/20

Tocris

Product number: 6614
Product name: Jedi2
Purity: ≥98%(HPLC)
Packaging: 50
Price: $590
Updated: 2021/12/16

Tocris

Product number: 6614
Product name: Jedi2
Purity: ≥98%(HPLC)
Packaging: 10
Price: $141
Updated: 2021/12/16

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2-Methyl-5-(2-thienyl)-3-furancarboxylic acid Chemical Properties,Usage,Production

Uses

Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770??μM[1].

Definition

ChEBI: 2-Methyl-5-(2-thienyl)-3-furoic acid is a furoic acid.

Biological Activity

Jedi2 is an activator of the mechanosensitive Piezo1 channel th at binds at a different place from Yoda1. It exhibits long-range allosteric gating, activating Piezo1 through the extracellular side of its peripheral blade-like structure rather than the C-terminal extracellular domain of the pore.

storage

Store at +4°C

References

[1] Yanfeng Wang, et al. A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat Commun. 2018 Apr 3;9(1):1300. DOI:10.1038/s41467-018-03570-9

2-Methyl-5-(2-thienyl)-3-furancarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methyl-5-(2-thienyl)-3-furancarboxylic acid Suppliers

China 31 United Kingdom 1 United States 5 Global 37

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651005-90-2, 2-Methyl-5-(2-thienyl)-3-furancarboxylic acidRelated Search:

2-Methyl-5-(2-thienyl)-3-furancarboxylic acid

Jedi2

Compound Fr13138

3-Furancarboxylic acid, 2-methyl-5-(2-thienyl)-

Jedi2, 10 mM in DMSO

651005-90-2