4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione

Product Name: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
CAS No.: 310460-39-0
Chemical Name: 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
Synonyms: CPYPP;CPYPP, 10 mM in DMSO;4-(3-(2-Chlorophenyl)allylidene)-1-phenylpyrazolidine-3,5-dione;4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione;3,5-Pyrazolidinedione, 4-[3-(2-chlorophenyl)-2-propen-1-ylidene]-1-phenyl-;DOCK2,CPYPP,Inhibitor,GEF,Rac1,DOCK180,lymphocytes,autoimmune,DOCK2-Rac1,inhibit,DOCK5,immunosuppressant,migration
CBNumber: CB34902763
Molecular Formula: C18H13ClN2O2
Formula Weight: 324.76
MOL File: 310460-39-0.mol

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4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione Property

Density: 1.405±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 50 mM
form: A crystalline solid
pka: 8.26±0.20(Predicted)
color: Brown to reddish brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 4568
Product name: CPYPP
Purity: ≥98%(HPLC)
Packaging: 10
Price: $115
Updated: 2021/12/16

Tocris

Product number: 4568
Product name: CPYPP
Purity: ≥98%(HPLC)
Packaging: 50
Price: $482
Updated: 2021/12/16

TRC

Product number: C781505
Product name: CPYPP
Packaging: 5mg
Price: $220
Updated: 2021/12/16

Ambeed

Product number: A1226465
Product name: 4-(3-(2-Chlorophenyl)allylidene)-1-phenylpyrazolidine-3,5-dione
Purity: 97%
Packaging: 25mg
Price: $106
Updated: 2021/12/16

Ambeed

Product number: A1226465
Product name: 4-(3-(2-Chlorophenyl)allylidene)-1-phenylpyrazolidine-3,5-dione
Purity: 97%
Packaging: 50mg
Price: $152
Updated: 2021/12/16

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4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione Chemical Properties,Usage,Production

Uses

CPYPP is a DOCK2-Rac1 interaction inhibitor. CPYPP binds to DOCK2 DHR-2 domain and inhibits the guanine nucleotide exchange factor (GEF) activity of DOCK2DHR-2 for Rac1 in a dose-dependent manner with an IC50 of 22.8 μM. CPYPP also inhibits DOCK180 and DOCK5 and less inhibits DOCK9[1].

in vivo

When 2.5 mg/kg of CPYPP is administrated intravenously, the plasma concentration of CPYPP is only 2.4 μM at 30 min. However, by intraperitoneally injecting 250 mg/kg of CPYPP into mice, the plasma concentration of CPYPP reached to 11.3 μM at 30 min and 10.9 μM at 1 hr, respectively^[1].
The adoptively transferred spleen cells from mice that has been made by a ‘‘knock-in’’ strategy to express endogenous DOCK2 as a fusion protein with green fluorescent protein (GFP). Intraperitoneal injection of CPYPP (5 mg per mouse) 1 hr before adoptive transfer reduces the percentage of the migrated T cells to <25% of the control level^[1].

storage

Store at -20°C

References

[1] Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97. DOI:10.1016/j.chembiol.2012.03.008

4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione Suppliers

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310460-39-0, 4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedioneRelated Search:

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DOCK2,CPYPP,Inhibitor,GEF,Rac1,DOCK180,lymphocytes,autoimmune,DOCK2-Rac1,inhibit,DOCK5,immunosuppressant,migration

CPYPP, 10 mM in DMSO

310460-39-0

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