6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride

Product Name: 6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride
CAS No.: 1638644-62-8
Chemical Name: 6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride
Synonyms: OD-36;OD-36,OD36;OD 36 hydrochloride;RIPK2 inhibitor OD36;6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine;13H-1,16-Etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine, 6-chloro-10,11,14,17-tetrahydro-;6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride
CBNumber: CB34902879
Molecular Formula: C16H15ClN4O2
Formula Weight: 330.77
MOL File: 1638644-62-8.mol

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6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride Property

Boiling point:: 501.7±50.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Desiccate at RT
solubility: Soluble in DMSO
form: Solid
pka: 4.79±0.20(Predicted)
color: White to off-white

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.32757
Product name: RIPK2 Inhibitor, OD36
Packaging: 5MG
Price: $156
Updated: 2026/03/19

Tocris

Product number: 6598
Product name: OD36hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $205
Updated: 2021/12/16

Usbiological

Product number: 461495
Product name: OD 36
Packaging: 1mg
Price: $368
Updated: 2021/12/16

TRC

Product number: O241600
Product name: OD36
Packaging: 1mg
Price: $90
Updated: 2021/12/16

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6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride Chemical Properties,Usage,Production

Uses

OD 36 is a potent and selective inhibitor of RIPK2 (Receptor-Interacting serine/threonine-Protein Kinase 2).

Biological Activity

Cell permeable: yes', 'Primary Target
RIPK2

in vivo

OD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model^[3].

Animal Model:	C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis^[3]
Dosage:	6.25 mg/kg
Administration:	Intraperitoneal injection, 30 min prior to MDP
Result:	Inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression.

IC 50

RIPK2: 5.3 nM (IC₅₀); ACVR1: 37 nM (Kd); ACVR1: 47 nM (IC₅₀); ALK2 R206H: 22 nM (IC₅₀)

storage

Desiccate at RT

6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride Suppliers

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1638644-62-8, 6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochlorideRelated Search:

6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride

OD-36

RIPK2 inhibitor OD36

OD 36 hydrochloride

13H-1,16-Etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine, 6-chloro-10,11,14,17-tetrahydro-

OD-36,OD36

6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine

1638644-62-8