ChemicalBook > CAS DataBase List > N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide

Product Name
N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
CAS No.
154563-54-9
Chemical Name
N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
Synonyms
SP 100030;SP-100030, 10 mM in DMSO;N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide;N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide;5-Pyrimidinecarboxamide, N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-
CBNumber
CB34902910
Molecular Formula
C14H5ClF9N3O
Formula Weight
437.65
MOL File
154563-54-9.mol
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N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide Property

Melting point:
166-167 °C
Boiling point:
340.6±42.0 °C(Predicted)
Density 
1.637±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
8.97±0.70(Predicted)
form 
Solid
color 
Off-white to light yellow
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
5309
Product name
SP100030
Purity
≥99%(HPLC)
Packaging
10
Price
$212
Updated
2021/12/16
Tocris
Product number
5309
Product name
SP100030
Purity
≥99%(HPLC)
Packaging
50
Price
$861
Updated
2021/12/16
Usbiological
Product number
256717
Product name
SP 100030
Packaging
10mg
Price
$460
Updated
2021/12/16
TRC
Product number
S681738
Product name
SP100030
Packaging
100mg
Price
$730
Updated
2021/12/16
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N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide Chemical Properties,Usage,Production

Uses

SP 100030 is a dual inhibitor of NF-κB and AP-1.

Biological Activity

Cell permeable: yes', 'Primary Target
AP-1 and NF-KB', 'Reversible: yes

in vivo

SP100030 (10 mg/kg/day; i.p.; day 21 to day 34) significantly decreased arthritis severity[2].

Animal Model:Six- to 8-wk-old male DBA/1J mice (immunized with type II collagen)[2]
Dosage:10 mg/kg
Administration:I.p.; daily, starting at day 21 to the end of the study on day 34
Result:Significantly decreased arthritis scores compared with controls; Histologic evaluation of the paws from mice treated from day 20 to 34 showed a trend toward decreased inflammation.

storage

Store at +4°C

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide Suppliers

China 32 United Kingdom 1 United States 4 USA 1 Global 38
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39999
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9550
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq：1580084073
Email
1580084073@qq.com
Country
China
ProdList
994
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
SINO High Goal Chemical Technology Co., Ltd.
Tel
021-57646680 18306277365
Email
guoxin@chembiobanksh.com
Country
China
ProdList
2697
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58

154563-54-9, N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamideRelated Search:


  • N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
  • SP 100030
  • 5-Pyrimidinecarboxamide, N-[3,5-bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-
  • N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide
  • SP-100030, 10 mM in DMSO
  • 154563-54-9