ChemicalBook > CAS DataBase List > DECANOYL-ARG-VAL-ARG-LYS-CHLOROMETHYLKETONE
DECANOYL-ARG-VAL-ARG-LYS-CHLOROMETHYLKETONE
- Product Name
- DECANOYL-ARG-VAL-ARG-LYS-CHLOROMETHYLKETONE
- CAS No.
- 534615-50-4
- Chemical Name
- DECANOYL-ARG-VAL-ARG-LYS-CHLOROMETHYLKETONE
- Synonyms
- Dec-RVRK-CMK;DECANOYL-ARG-VAL-ARG-LYS-CMK;DECANOYL-ARG-VAL-ARG-LYS-CHLOROMETHYLKETONE;L-Argininamide, N2-(1-oxodecyl)-L-arginyl-L-valyl-N-[(1S)-5-amino-1-(2-chloroacetyl)pentyl]-
- CBNumber
- CB3491450
- Molecular Formula
- C34H66ClN11O5
- Formula Weight
- 744.41
- MOL File
- Mol file
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DECANOYL-ARG-VAL-ARG-LYS-CHLOROMETHYLKETONE Property
- storage temp.
- -15°C
- Sequence
- {DEC}-Arg-Val-Arg-Lys-{CMK}
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N-Bromosuccinimide Price
Biosynth Carbosynth
- Product number
- FD111052
- Product name
- Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
- Packaging
- 500ug
- Price
- $150
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD111052
- Product name
- Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
- Packaging
- 1mg
- Price
- $264
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD111052
- Product name
- Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
- Packaging
- 2mg
- Price
- $459
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- PEP0011715
- Product name
- DEC-RVRK-CMK
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.16
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD111052
- Product name
- Decanoyl-Arg-Val-Arg-Lys-chloromethylketone
- Packaging
- 5mg
- Price
- $918
- Updated
- 2021/12/16
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DECANOYL-ARG-VAL-ARG-LYS-CHLOROMETHYLKETONE Chemical Properties,Usage,Production
Uses
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position[1].
References
[1] Wheatley JL, et al. Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6626-31. DOI:10.1073/pnas.0701983104
DECANOYL-ARG-VAL-ARG-LYS-CHLOROMETHYLKETONE Preparation Products And Raw materials
Raw materials
Preparation Products
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DECANOYL-ARG-VAL-ARG-LYS-CHLOROMETHYLKETONE Suppliers
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