ChemicalBook > CAS DataBase List > Mizagliflozin

Mizagliflozin

Product Name: Mizagliflozin
CAS No.: 666843-10-3
Chemical Name: Mizagliflozin
Synonyms: KGA3235;KGA 3235;KGA-3235;GSK1614235;GSK-1614235;GSK 1614235;Mizagliflozin;DSP-3235 free base;KGA-3235 free base;GSK-1614235 free base
CBNumber: CB34919871
Molecular Formula: C28H44N4O8
Formula Weight: 564.68
MOL File: 666843-10-3.mol

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Mizagliflozin Property

Boiling point:: 837.0±65.0 °C(Predicted)
Density: 1.274±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: Methanol: 250 mg/mL (442.74 mM); DMSO: 100 mg/mL (177.09 mM)
form: Solid
pka: 12.65±0.70(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0016832
Product name: Mizagliflozin
Purity: 99.64%
Packaging: 5mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-0016832
Product name: Mizagliflozin
Purity: 99.64%
Packaging: 10mg
Price: $800
Updated: 2021/12/16

ChemScene

Product number: CS-0016832
Product name: Mizagliflozin
Purity: 99.64%
Packaging: 25mg
Price: $1600
Updated: 2021/12/16

ChemScene

Product number: CS-0016832
Product name: Mizagliflozin
Purity: 99.64%
Packaging: 50mg
Price: $2500
Updated: 2021/12/16

ChemScene

Product number: CS-0016832
Product name: Mizagliflozin
Purity: 99.64%
Packaging: 100mg
Price: $4000
Updated: 2021/12/16

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Mizagliflozin Chemical Properties,Usage,Production

Uses

Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a Ki of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic agent that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation[1].

in vivo

Mizagliflozin (DSP-3235 free base) (3-30 mg/kg; oral) exerts a laxative effect^[1].
Mizagliflozin administrated intravenously (0.3 mg/kg) and orally (3 mg/kg) declined with a short half-life (0.23 and 1.14 h, respectively)^[2]

Animal Model:	Male Wistar rats (rat model of low-fiber-diet-induced constipation)^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	Oral
Result:	Increased fecal wet weight in a rat model of low-fiber-diet-induced constipation.

IC 50

SGLT1

References

[1] Inoue T, et al. Mizagliflozin, a novel selective SGLT1 inhibitor, exhibits potential in the amelioration of chronic constipation. Eur J Pharmacol. 2017 Jul 5;806:25-31. DOI:10.1016/j.ejphar.2017.04.010
[2] Ohno H, et al. Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats. Xenobiotica. 2019 Apr;49(4):463-473. DOI:10.1080/00498254.2018.1449269

Mizagliflozin Preparation Products And Raw materials

Raw materials

Preparation Products

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666843-10-3, MizagliflozinRelated Search:

Mizagliflozin

DSP-3235 free base

GSK-1614235 free base

KGA-3235 free base

Propanamide, 3-[[3-[4-[[3-(β-D-glucopyranosyloxy)-5-(1-methylethyl)-1H-pyrazol-4-yl]methyl]-3-methylphenoxy]propyl]amino]-2,2-dimethyl-

GSK1614235,Chronic,KGA 3235,DSP-3235,selective,Sodium-dependent glucose cotransporters,KGA-3235,constipation,Mizagliflozin,antidiabetic,disorder,SGLT,gastrointestinal,DSP 3235,inhibit,GSK 1614235,Inhibitor,KGA3235,GSK-1614235,DSP3235

Mizagliflozin (KWA 0711)

GSK 1614235

GSK1614235

GSK-1614235

KGA 3235

KGA3235

KGA-3235

3-((3-(4-((5-Isopropyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1H-pyrazol-4-yl)methyl)-3-methylphenoxy)propyl)amino)-2,2-dimethylpropanamide

Mizagliflozin, 10 mM in DMSO

666843-10-3

C28H44N4O8