1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL

Product Name: 1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL
CAS No.: 401930-07-2
Chemical Name: 1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL
Synonyms: 1-[4-(TRIFLUOROMETHYL)-2-PYRIMIDINYL]-4-PIPERIDINOL;1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL;4-Piperidinol, 1-[4-(trifluoromethyl)-2-pyrimidinyl]-;1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperidin-4-ol97%;1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperidin-4-ol 97%;1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperidin-4-ol 95+%;1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL ISO 9001：2015 REACH
CBNumber: CB3492437
Molecular Formula: C10H12F3N3O
Formula Weight: 247.22
MOL File: 401930-07-2.mol

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1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL Property

Melting point:: 99 °C
Boiling point:: 366.4±52.0 °C(Predicted)
Density: 1.383
storage temp.: Sealed in dry,Room Temperature
pka: 14.51±0.20(Predicted)

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Safety

Hazard Note: Harmful
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC2931
Product name: 1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperidin-4-ol
Purity: 95+%
Packaging: 250mg
Price: $49
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-3-U8
Product name: 1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperidin-4-ol
Purity: 97%
Packaging: 250mg
Price: $79
Updated: 2021/12/16

AK Scientific

Product number: Y9018
Product name: 1-[4-(Trifluoromethyl)-2-pyrimidinyl]-4-piperidinol
Packaging: 250mg
Price: $119
Updated: 2021/12/16

Apolloscientific

Product number: PC2931
Product name: 1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperidin-4-ol
Purity: 95+%
Packaging: 1g
Price: $121
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-3-U8
Product name: 1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperidin-4-ol
Purity: 97%
Packaging: 1g
Price: $194
Updated: 2021/12/16

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1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL Chemical Properties,Usage,Production

Synthesis

5382-16-1

33034-67-2

401930-07-2

Using 4-hydroxypiperidine (1.65 g, 16.3 mmol) and 2-chloro-4-trifluoromethylpyrimidine (2.98 g, 16.3 mmol) as the raw material, triethylamine (4.5 mL, 32.7 mmol) was added to isopropanol (60 mL) and the mixture was heated and refluxed for 5 hours. Upon completion of the reaction, it was cooled to room temperature and diluted with hexane and white precipitate formation was observed. The solids were removed by filtration and the filtrate was subsequently purified by passing it through a silica plug and washed sequentially with a 1:1 solvent mixture of EtOAc/hexane and pure EtOAc. The collected filtrate and washings were combined and concentrated to dryness to afford the target product 1-[4-(trifluoromethyl)-2-pyrimidinyl]-4-piperidinol (3.89 g). The exact mass calculated value of the product (C10H11F3N2O) was 247.09 and the measured LCMS value was 248.2 [M+H]+.

References

[1] British Journal of Pharmacology, 2014, vol. 171, # 24, p. 5774 - 5789
[2] Patent: WO2014/74700, 2014, A1. Location in patent: Page/Page column 58

1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-TRIFLUOROMETHYL-PYRIMIDIN-2-YL)-PIPERIDIN-4-OL Suppliers

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