2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE
- Product Name
- 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE
- CAS No.
- 60611-24-7
- Chemical Name
- 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE
- Synonyms
- OTF-BAD-6F;4-Fluoro-5'-hydroxybenzopheone;2-Fluoro-6-trifluorobenzaldehyde;α,α,α,6-Tetrafluoro-o-tolualdehyde;α,α,α,6-Tetrafluoro-2-tolualdehyde;à,à,à,6-tetrafluoro-o-tolualdehyde;2-fluoro-6-(trifluoromethyl)benzald;2-Fluor-6-trifluormethylbenzaldehyd;2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE;Benzaldehyde, 2-fluoro-6-(trifluoromethyl)-
- CBNumber
- CB3492563
- Molecular Formula
- C8H4F4O
- Formula Weight
- 192.11
- MOL File
- 60611-24-7.mol
2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE Property
- Melting point:
- 155-157°C
- Boiling point:
- 156 °C (lit.)
- Density
- 1.432 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.458(lit.)
- Flash point:
- 179 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Almost colorless
- Sensitive
- Air Sensitive
- BRN
- 2263481
- InChI
- InChI=1S/C8H4F4O/c9-7-3-1-2-6(5(7)4-13)8(10,11)12/h1-4H
- InChIKey
- FAKUGVHRTLCKHB-UHFFFAOYSA-N
- SMILES
- C(=O)C1=C(C(F)(F)F)C=CC=C1F
- CAS DataBase Reference
- 60611-24-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 436089
- Product name
- 2-Fluoro-6-(trifluoromethyl)benzaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $38
- Updated
- 2023/01/07
- Product number
- F1033
- Product name
- 2-Fluoro-6-(trifluoromethyl)benzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- F1033
- Product name
- 2-Fluoro-6-(trifluoromethyl)benzaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $136
- Updated
- 2025/07/31
- Product number
- F599048
- Product name
- 2-Fluoro-6-(trifluoromethyl)benzaldehyde
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 002739
- Product name
- 2-Fluoro-6-(trifluoromethyl)benzaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $41
- Updated
- 2021/12/16
2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE Chemical Properties,Usage,Production
Uses
2-Fluoro-6-(trifluoromethyl)benzaldehyde may be employed for the synthesis of diaryl ether, 2-(3,5-dimethoxyphenoxy)-6-(trifluoromethyl)- benzonitrile and substituted benzo[b]thiophene-2-carboxylates.
General Description
2-Fluoro-6-(trifluoromethyl)benzaldehyde participates in the synthesis of 2-amino-5-trifluoromethylquinazoline.
Synthesis
401-80-9
68-12-2
60611-24-7
In a 5L three-necked round-bottomed flask, 3-fluorobenzotrifluoride (492.0 g, 3.0 mol), N,N,N',N'-tetramethylethylenediamine (TMEDA, 383.2 g, 3.3 mol), diisopropylamine (DIPA, 21.3 g, 0.16 mol), and anhydrous tetrahydrofuran (THF, 1.5 L) were added and the reaction system was cooled to -70 to - 78 °C. A solution of n-butyllithium (n-BuLi, 211.5 g, 3.3 mol) was slowly added dropwise at -70 to -78 °C. The reaction was maintained at this temperature for 2 to 3 hours. Subsequently, N,N-dimethylformamide (DMF, 328.7 g, 4.5 mol) was slowly added and the reaction was continued at this temperature for 1-2 hours. After completion of the reaction, it was slowly warmed up to room temperature, the reaction was quenched with saturated ammonium chloride (NH4Cl) solution (500 ml) and extracted with ethyl acetate (500 ml x 3). The organic layers were combined and concentrated to dryness to give 510.1 g of the solid product 2-fluoro-6-trifluoromethylbenzaldehyde in 88.7% yield.
References
[1] Patent: CN107935863, 2018, A. Location in patent: Paragraph 0040-0043; 0053-0054; 0060-0061
[2] Tetrahedron Letters, 1992, vol. 33, # 49, p. 7499 - 7502
[3] Tetrahedron Letters, 2013, vol. 54, # 45, p. 6053 - 6056
2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE manufacturers
- Product
- 2-FLUORO-6-(TRIFLUOROMETHYL)BENZALDEHYDE 60611-24-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-13
- Product
- 2-Fluoro-6-(trifluoromethyl)benzaldehyde 60611-24-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25