CGP74514A
- Product Name
- CGP74514A
- CAS No.
- 481724-82-7
- Chemical Name
- CGP74514A
- Synonyms
- CGP74514A;AURORA KA-7574;CGP-74514A hydrochloride (CGP74514A);N-(CIS-2-AMINOCYCLOHEXYL)-N-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE;N-[(1R,2S)-2-Aminocyclohexyl]-N'-(3-Chlorophenyl)-9-Ethylpurine-2,6-Diamine;2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine:hydrochloride;9H-Purine-2,6-diamine, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-, monohydrochloride, rel- (9CI)
- CBNumber
- CB3495872
- Molecular Formula
- C19H24ClN7
- Formula Weight
- 385.89
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- KIN0000967
- Product name
- CGP-74514A
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $514.5
- Updated
- 2021/12/16
CGP74514A Chemical Properties,Usage,Production
Description
CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and Bcl-x(L). CGP74514A treatment (5 microM; 18 hr) resulted in increased p21(CIP1) expression, p27(KIP1) degradation, diminished E2F1 expression, and dephosphorylation of p34(CDC2). It also induced early (i.e., within 2 hr) inhibition of CDK1 activity and dephosphorylation of pRb, followed by pRb degradation, but did not block pRb phosphorylation at CDK2- and CDK4- specific sites. These findings indicate that the selective CDK1 inhibitor, CGP74514A , induces complex changes in cell cycle-related proteins in human leukemia cells accompanied by extensive mitochondrial damage, caspase activation, and apoptosis.
CGP74514A Preparation Products And Raw materials
Raw materials
Preparation Products
CGP74514A Suppliers
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
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- Advantage
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- Tel
- 15002134094
- marketing@targetmol.com
- Country
- China
- ProdList
- 24246
- Advantage
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