CGP74514A

Product Name: CGP74514A
CAS No.: 481724-82-7
Chemical Name: CGP74514A
Synonyms: CGP74514A;AURORA KA-7574;CGP-74514A hydrochloride (CGP74514A);N-(CIS-2-AMINOCYCLOHEXYL)-N-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE;N-[(1R,2S)-2-Aminocyclohexyl]-N'-(3-Chlorophenyl)-9-Ethylpurine-2,6-Diamine;2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine:hydrochloride;9H-Purine-2,6-diamine, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-, monohydrochloride, rel- (9CI)
CBNumber: CB3495872
Molecular Formula: C19H24ClN7
Formula Weight: 385.89
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: KIN0000967
Product name: CGP-74514A
Purity: 95.00%
Packaging: 5MG
Price: $514.5
Updated: 2021/12/16

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CGP74514A Chemical Properties,Usage,Production

Description

CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and Bcl-x(L). CGP74514A treatment (5 microM; 18 hr) resulted in increased p21(CIP1) expression, p27(KIP1) degradation, diminished E2F1 expression, and dephosphorylation of p34(CDC2). It also induced early (i.e., within 2 hr) inhibition of CDK1 activity and dephosphorylation of pRb, followed by pRb degradation, but did not block pRb phosphorylation at CDK2- and CDK4- specific sites. These findings indicate that the selective CDK1 inhibitor, CGP74514A , induces complex changes in cell cycle-related proteins in human leukemia cells accompanied by extensive mitochondrial damage, caspase activation, and apoptosis.

CGP74514A Preparation Products And Raw materials

Raw materials

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CGP74514A Suppliers

Austria 1 CHINA 14 Switzerland 1 United States 3 Global 19

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19885
Advantage: 58

Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

EMD Biosciences, Inc.

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Email: technical@calbiochem.com
Country: United States
ProdList: 6529
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481724-82-7, CGP74514ARelated Search:

CGP-74514A hydrochloride (CGP74514A)

N-[(1R,2S)-2-Aminocyclohexyl]-N'-(3-Chlorophenyl)-9-Ethylpurine-2,6-Diamine

N-(CIS-2-AMINOCYCLOHEXYL)-N-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE

AURORA KA-7574

CGP74514A

9H-Purine-2,6-diamine, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-, monohydrochloride, rel- (9CI)

2-N-[(1R,2S)-2-aminocyclohexyl]-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine:hydrochloride

481724-82-7

C19H24ClN7ClH