CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-
- Product Name
- CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-
- CAS No.
- 92285-01-3
- Chemical Name
- CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-
- Synonyms
- Ajoene;E/Z Ajoene;CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9-;(Z)-4,5,9-Trithiadodeca-1,6,11-triene-9-oxide;2-Propenyl(4,5-dithia-2,7-octadiene-1-yl) sulfoxide;2-Propenyl 3-(2-propenylsulfinyl)-1-propenyl persulfide;Allyl[(2E)-3-(allyldisulfanyl)-2-propen-1-yl]sulfoniumolate;(2-Propenyl)[3-[(2-propenyl)sulfinyl]-1-propenyl] persulfide;(Z)-1-(prop-2-enyldisulfanyl)-3-prop-2-enylsulfinylprop-1-ene;Disulfide, 2-propen-1-yl [3-(2-propen-1-ylsulfinyl)-1-propen-1-yl]
- CBNumber
- CB3497346
- Molecular Formula
- C9H14OS3
- Formula Weight
- 234.4
- MOL File
- 92285-01-3.mol
CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9- Property
- Boiling point:
- 376.0±42.0 °C(Predicted)
- Density
- 1.181±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Chloroform: slightly soluble,Ethyl Acetate: slightly soluble,Methanol: slightly soluble
- form
- Liquid
- color
- Colorless to light yellow
- LogP
- 2.536 (est)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26242
- Product name
- Ajoene
- Packaging
- 2.5mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- API0015045
- Product name
- AJOENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.7
- Updated
- 2021/12/16
- Product number
- 67692
- Product name
- E/ZAjoene
- Packaging
- 2.5mg
- Price
- $590
- Updated
- 2021/12/16
CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9- Chemical Properties,Usage,Production
Uses
Ajoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities[1][2].
Definition
ChEBI: (E)-Ajoene is a sulfoxide.
Anticancer Research
It is an organosulfur compound obtained from garlic and induces apoptosis in leukemiacells (Aggarwal and Shishodia 2004). Ajoene demonstrated a significantcytotoxic activity in different cancer cell lines including FS4 (human primaryfibroblast), BHK21 (a permanent and non-tumorigenic cell line derived from kidneycells of baby hamster), and BJA-B (tumorigenic lymphoid cell line derived fromBurkitt lymphoma) (Scharfenberg et al. 1990)
in vivo
Ajoene (25 μg/g body weight of Ajoene in 100 mL Intralipid; i.p.; every other day from the day of inoculation up to day 28) inhibits both primary tumor growth[1].
Ajoene (25, 15 or 5 μg/g body weight of Ajoene in 100 μL Intralipid; i.p; every other day over 4 weeks) inhibits strongly metastasis to lung in the B16/BL6 melanoma tumor model in C57BL/6 mice[1].
References
[1] Taylor P, et al. Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice. Cancer Lett. 2006;239(2):298-304. DOI:10.1016/j.canlet.2005.08.022
[2] Ahmed N, et al. Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells. Anticancer Res. 2001;21(5):3519-3523. PMID:11848518
CIS-4,5,9-TRITHIADODECA-1,6,11-TRIENE-9- Preparation Products And Raw materials
Raw materials
Preparation Products
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