ADENOSINE AMINE CONGENER (ADAC)

Product Name: ADENOSINE AMINE CONGENER (ADAC)
CAS No.: 96760-69-9
Chemical Name: ADENOSINE AMINE CONGENER (ADAC)
Synonyms: ADENOSINE AMINE CONGENER (ADAC);Adenosine amine congener hydrate;Adenosine amine congener, 10 mM in DMSO;N-[4-[2-[[4-[2-[(2-Aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2-oxoethyl]phenyl]adenosine;Adenosine, N-[4-[2-[[4-[2-[(2-aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2-oxoethyl]phenyl]-;N6-[4-[[[4-[[[(2-AMinoethyl)aMino]carbonyl]Methyl]-anilino]carbonyl]Methyl]phenyl]adenosine hydrate;ADAC, N6-[4-[[[4-[[[(2-Aminoethyl)amino]carbonyl]methyl]-anilino]carbonyl]methyl]phenyl]adenosine hydrate;N-(2-aminoethyl)-2-(4-{2-[4-({9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-yl}amino)phenyl]acetamido}phenyl)acetamide;N-(2-Aminoethyl)-2-(4-(2-(4-((9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)phenyl)acetamido)phenyl)acetamide;P1 receptor,otoprotective,Adenosine amine congener,Adenosine Receptor,loss,hearing,Inhibitor,apoptotic,injury,systemic,A1-adenosine,Cochlear,inhibit,Ca2+,neuroprotective
CBNumber: CB3497841
Molecular Formula: C28H32N8O6
Formula Weight: 576.6
MOL File: 96760-69-9.mol

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ADENOSINE AMINE CONGENER (ADAC) Property

Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: 0.1 M acetic acid: 12 mM
pka: 13.11±0.70(Predicted)
form: solid
color: white

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Safety

Safety Statements: 22-24/25
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A111
Product name: Adenosine amine congener hydrate
Purity: solid, ≥98% (HPLC)
Packaging: 25mg
Price: $737
Updated: 2023/01/07

Sigma-Aldrich

Product number: A111
Product name: Adenosine amine congener hydrate
Purity: solid, ≥98% (HPLC)
Packaging: 5mg
Price: $188
Updated: 2022/05/15

ChemScene

Product number: CS-0095160
Product name: Adenosineaminecongener
Purity: 99.23%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

CSNpharm

Product number: CSN25244
Product name: Adenosineaminecongener
Packaging: 1mg
Price: $80
Updated: 2021/12/16

CSNpharm

Product number: CSN25244
Product name: Adenosineaminecongener
Packaging: 5mg
Price: $130
Updated: 2021/12/16

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ADENOSINE AMINE CONGENER (ADAC) Chemical Properties,Usage,Production

Uses

Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects[1][2].

in vivo

Adenosine amine congener (25-300?μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50?μg/kg, providing up to 21?dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner^[1].

Animal Model:	Male Wistar rats (8-10 weeks old) treated with noise exposure^[1]
Dosage:	25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300?μg/kg/day
Administration:	Intraperitoneal injection; daily; for 5 days
Result:	Most effective in the first 24 hours after noise exposure at doses >50?μg/kg, and provided up to 21?dB protection (averaged across 8-28?kHz).

References

[1] Vlajkovic SM, et al. Adenosine amine congener as a cochlear rescue agent. Biomed Res Int. 2014;2014:841489. DOI:10.1155/2014/841489
[2] Vlajkovic SM, et al. Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signal. 2010 Jun;6(2):273-81. DOI:10.1007/s11302-010-9188-5

ADENOSINE AMINE CONGENER (ADAC) Preparation Products And Raw materials

Raw materials

Preparation Products

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ADENOSINE AMINE CONGENER (ADAC) Suppliers

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96760-69-9, ADENOSINE AMINE CONGENER (ADAC)Related Search:

6-ANILINOPURINE 4-(2-METHYLAMINO-ETHYL)-PHENYLAMINE 2,N-DIPHENYLACETAMIDE N6-METHYL-2'-DEOXY-ADENOSINE ADENOSINE AMINE CONGENER (ADAC) PHENETHYL-PHENYL-AMINE 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE N6-PHENYLADENOSINE N-[4-(2-aminoethyl)phenyl]acetamide

N6-[4-[[[4-[[[(2-AMinoethyl)aMino]carbonyl]Methyl]-anilino]carbonyl]Methyl]phenyl]adenosine hydrate

ADENOSINE AMINE CONGENER (ADAC)

ADAC, N6-[4-[[[4-[[[(2-Aminoethyl)amino]carbonyl]methyl]-anilino]carbonyl]methyl]phenyl]adenosine hydrate

Adenosine amine congener hydrate

N-[4-[2-[[4-[2-[(2-Aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2-oxoethyl]phenyl]adenosine

Adenosine, N-[4-[2-[[4-[2-[(2-aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2-oxoethyl]phenyl]-

N-(2-Aminoethyl)-2-(4-(2-(4-((9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)phenyl)acetamido)phenyl)acetamide

P1 receptor,otoprotective,Adenosine amine congener,Adenosine Receptor,loss,hearing,Inhibitor,apoptotic,injury,systemic,A1-adenosine,Cochlear,inhibit,Ca2+,neuroprotective

N-(2-aminoethyl)-2-(4-{2-[4-({9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-yl}amino)phenyl]acetamido}phenyl)acetamide

Adenosine amine congener, 10 mM in DMSO

96760-69-9

C28H32N8O6

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