4-AMINO-2-IODOBENZONITRILE 98

Product Name: 4-AMINO-2-IODOBENZONITRILE 98
CAS No.: 33348-34-4
Chemical Name: 4-AMINO-2-IODOBENZONITRILE 98
Synonyms: 4-amino-2-iodobenzonitrile;3-Iodo-4-aMinobenzonitrile;1-Amino-2-iodo-4-cyanobenzene;Benzonitrile, 4-amino-3-iodo-;4-AMINO-2-IODOBENZONITRILE 98;4-AMino-3-iodobenzonitrile 98%;4-AMINO-2-IODOBENZONITRILE 98%
CBNumber: CB3498631
Molecular Formula: C7H5IN2
Formula Weight: 244.03
MOL File: 33348-34-4.mol

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4-AMINO-2-IODOBENZONITRILE 98 Property

Melting point:: 112-115 °C (lit.)
Boiling point:: 328.3±37.0 °C(Predicted)
Density: 1.98±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to crystal
pka: -0.34±0.10(Predicted)
color: White to Amber
Sensitive: Light Sensitive
InChI: InChI=1S/C7H5IN2/c8-6-3-5(4-9)1-2-7(6)10/h1-3H,10H2
InChIKey: UOWVTQFTEAYDLM-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=C(N)C(I)=C1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: 3439
WGK Germany: 3
HS Code: 2926.90.4801
HazardClass: 6.1
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 657123
Product name: 4-Amino-3-iodobenzonitrile
Purity: 98%
Packaging: 5g
Price: $80.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 657123
Product name: 4-Amino-3-iodobenzonitrile
Purity: 98%
Packaging: 1g
Price: $32.5
Updated: 2023/06/20

TCI Chemical

Product number: A2747
Product name: 4-Amino-3-iodobenzonitrile
Purity: >98.0%(GC)
Packaging: 1g
Price: $80
Updated: 2025/07/31

TCI Chemical

Product number: A2747
Product name: 4-Amino-3-iodobenzonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $249
Updated: 2025/07/31

TRC

Product number: A577275
Product name: 4-Amino-3-Iodobenzonitrile
Packaging: 500mg
Price: $60
Updated: 2021/12/16

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4-AMINO-2-IODOBENZONITRILE 98 Chemical Properties,Usage,Production

Chemical Properties

Off-white crystalline

Uses

Reactant involved in:

Hydroamination-double hydroarylation for synthesis of fuzed carbazoles
Cycloisomerizations of aromatic homo- and bis-homopropargylic amine / amide intermediates
Asymmetric organocatalytic condensation and cycloaddition
Regioselective aryl C-H bond functionalization
Synthesis of [(triisopropylsilyl)ethynyl]indole derivatives
Domino condensation / S-arylation / heterocyclization reactions

Uses

Palladium-catalyzed carbonylation of iodoanilines provides ketoamides in the presence of primary and secondary amines.8

Synthesis

873-74-5

33348-34-4

General procedure for the synthesis of 4-amino-3-iodobenzonitrile from 4-aminobenzonitrile: To a methanol (30 mL) solution of 4-aminobenzonitrile (2.4 g, 20 mmol) and 30% H2O2 (not titrated prior to use), a methanol (50 mL) solution of iodine (5.05 g, 12 mmol) was added at room temperature. The reaction mixture was stirred at room temperature for 48 hours, during which time it was replenished daily with fresh H2O2 (2 mL). Upon completion of the reaction, the mixture was concentrated under reduced pressure and treated with saturated Na2S2O3 solution until most of the color disappeared. The precipitated solid was collected by filtration, and the filtrate was diluted to 300 mL with ethyl acetate, washed sequentially with saturated aqueous NaHCO3 solution, brine, and dried with anhydrous MgSO4. After filtration, the filtrate was concentrated to dryness under reduced pressure. The crude product was initially purified by crystallization from ethanol to give 4-amino-3-iodobenzonitrile (3 g). The residue was further recrystallized from dichloromethane/hexane mixed solvent to give additional 4-amino-3-iodobenzonitrile (1.4 g). The total yield was 4.4 g (88%). The structure of the product was confirmed by 1H NMR (CDCl3): δ 7.87 (d, 1H, J = 1.8 Hz), 7.37 (dd, 1H, J = 1.8, 8.4 Hz), 6.68 (d, 1H, J = 8.4 Hz), 4.62 (br s, 2H).

References

[1] Journal of the American Chemical Society, 2008, vol. 130, # 43, p. 14339 - 14345
[2] European Journal of Organic Chemistry, 2001, # 24, p. 4607 - 4613
[3] Organic Letters, 2005, vol. 7, # 13, p. 2543 - 2546
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 9, p. 2722 - 2725
[5] Patent: WO2014/63199, 2014, A1. Location in patent: Page/Page column 56

4-AMINO-2-IODOBENZONITRILE 98 Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-2-IODOBENZONITRILE 98 Suppliers

Americas 1 China 131 Europe 1 India 9 Japan 1 Switzerland 1 United Kingdom 2 United States 13 Global 159

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View Lastest Price from 4-AMINO-2-IODOBENZONITRILE 98 manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-AMINO-2-IODOBENZONITRILE 33348-34-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-12

Shaanxi Dideu Medichem Co. Ltd

Product: 4-AMINO-2-IODOBENZONITRILE 98 33348-34-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-01

Career Henan Chemical Co

Product: 4-AMINO-2-IODOBENZONITRILE 98 33348-34-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

33348-34-4, 4-AMINO-2-IODOBENZONITRILE 98Related Search:

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33348-34-4

IC6H3NH2CN

Building Blocks

C6 to C7

Chemical Synthesis

Cyanides/Nitriles

Nitrogen Compounds

Organic Building Blocks