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HISPIDIN

Product Name
HISPIDIN
CAS No.
555-55-5
Chemical Name
HISPIDIN
Synonyms
Hispidine;Hispidin - CAS 555-55-5 - Calbiochem;6-(3,4-Dihydroxystyryl)-4-hydroxy-2-pyrone;6-(3,4-Dihydroxystyryl)-4-hydroxy-2H-pyran-2-one;(E)-6-(3,4-Dihydroxystyryl)-4-hydroxy-2H-pyran-2-one;4-hydroxy-6-(3,4-dihydroxystyryl)-2-pyrone (hispidine);2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-4-pyranone;6-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]-4-hydroxy-2H-pyran-2-one;(E)-6-[2-(3,4-Dihydroxyphenyl)ethenyl]-4-hydroxy-2H-pyran-2-one;6-[(1E)-2-(3,4-Dihydroxyphenyl)ethenyl]-4-hydroxy-2H-pyran-2-one
CBNumber
CB3500046
Molecular Formula
C13H10O5
Formula Weight
246.22
MOL File
555-55-5.mol
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HISPIDIN Property

Melting point:
312-315℃
Boiling point:
500.5±50.0 °C(Predicted)
Density 
1.657
storage temp. 
-20°C
solubility 
DMSO: >10 mg/mL
form 
solid
pka
4.90±0.30(Predicted)
color 
yellow to brown
λmax
369nm(MeOH)(lit.)
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Safety

WGK Germany 
3
HS Code 
2932.20.3000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H5257
Product name
Hispidin
Purity
solid, ≥98% (HPLC)
Packaging
5mg
Price
$416
Updated
2024/03/01
Sigma-Aldrich
Product number
377980
Product name
Hispidin
Packaging
2mg
Price
$419
Updated
2023/01/07
TCI Chemical
Product number
H1661
Product name
Hispidin
Purity
>98.0%(HPLC)
Packaging
10mg
Price
$348
Updated
2024/03/01
TCI Chemical
Product number
H1661
Product name
Hispidin
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$1042
Updated
2024/03/01
Cayman Chemical
Product number
10012605
Product name
Hispidin
Purity
≥95%
Packaging
1mg
Price
$93
Updated
2024/03/01
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HISPIDIN Chemical Properties,Usage,Production

Description

Hispidin is a polyphenol originally isolated from P. hispidus that has diverse biological activities, including antioxidant, anti-inflammatory, and cytoprotective properties. In a trolox equivalent antioxidant capacity (TEAC) assay, hispidin scavenges radicals at 14.47 equivalents of trolox . It inhibits transcriptional activity of NF-κB, decreases inducible nitric oxide synthase (iNOS) expression, and decreases the generation of reactive oxygen species (ROS) in LPS-induced macrophage RAW 264.7 cells. Hispidin inhibits apoptosis and increases insulin secretion in hydrogen peroxide-treated RINm5F pancreatic β-cells. It inhibits protein kinase C β (PKCβ; IC50 = 2 μM) with no activity against alkaline phosphatase. Hispidin also inhibits β-secretase (BACE1; IC50 = 4.9 μM) and prolyl endopeptidase (PE; IC50 = 16 μM) but not other serine proteases when used at a concentration of 40 μM (0.6, 0, 8.2, and 3.1% inhibition of chymotrypsin, trypsin, elastase, and tumor necrosis factor-α converting enzyme (TACE), respectively).

Uses

Hispidin is a naturally occuring precursor to fungal luciferin responsible for luminosity in mushrooms.

Definition

ChEBI: Fungal metabolite first found in basidiomycete Inonotus hispidus (formerly Polyporus hispidus).

General Description

Hispidin is a phenolic compound, that is obtained from a medicinal mushroom, Phellinus linteus.

Biochem/physiol Actions

Hispidin exhibits robust antioxidant, anticancer and antidiabetic properties. It has the ability to guard against peroxynitrite-mediated cytotoxicity, DNA damage and the development of hydroxyl radicals.

in vitro

in previous study hispidin was found to reduce cell viability in both mouse and human colon cancer cells, and the apoptotic cell morphological changes were also observed. these results showed accumulation of the sub-g1 cell population and increase in early apoptosis dose-dependently. moreover, hispidin could induce apoptosis via up-regulation of both intrinsic and extrinsic apoptotic pathways. although the molecular mechanism underlying hispidin-induced apoptosis was known to involve the generation of ros, however hispidin was not able to display any apoptosis in the pre-treatment with n-acetyl-l-cysteine, a ros scavenger [1].

in vivo

previous animal study found that the treatment with pkc-activating agent phorbol-12-myristate-13-acetate could attenuate exendin-4-induced relaxations and reduced glp-1r expression in wistar-kyoto rat arteries, which were reversed by hispidin [2].

IC 50

2 μm

References

[1] lim jh, lee ym, park sr, kim dh, lim bo. anticancer activity of hispidin via reactive oxygen species-mediated apoptosis in colon cancer cells. anticancer res. 2014 aug;34(8):4087-93.
[2] liu l, liu j, gao y, ng cf, yu x, dou d, huang y. protein kinase cβ mediates downregulated expression of glucagon-like peptide-1 receptor in hypertensive rat renal arteries. j hypertens. 2015 apr;33(4):784-90; discussion 790.

HISPIDIN Preparation Products And Raw materials

Raw materials

Preparation Products

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HISPIDIN Suppliers

Americas 1 China 56 Europe 1 India 1 Japan 1 Switzerland 1 United States 11 Global 72
Wuhan ariel chemical Co., LTD.
Tel
18986259541 18986259541
Fax
027-87840182
Email
sales@3stc.com
Country
China
ProdList
3998
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9649
Advantage
58
Lihe Wuhan New Chemical Materials Co., Ltd.
Tel
027-88395709
Fax
027-88391805
Country
China
ProdList
429
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80

555-55-5, HISPIDINRelated Search:

Ethylamine (-)-Varitriol

  • Hispidin - CAS 555-55-5 - Calbiochem
  • 6-[(E)-2-(3,4-Dihydroxyphenyl)vinyl]-4-hydroxy-2H-pyran-2-one
  • 4-hydroxy-6-(3,4-dihydroxystyryl)-2-pyrone (hispidine)
  • (E)-6-[2-(3,4-Dihydroxyphenyl)ethenyl]-4-hydroxy-2H-pyran-2-one
  • 6-(3,4-Dihydroxystyryl)-4-hydroxy-2H-pyran-2-one
  • 6-(3,4-Dihydroxystyryl)-4-hydroxy-2-pyrone
  • 6-[(1E)-2-(3,4-Dihydroxyphenyl)ethenyl]-4-hydroxy-2H-pyran-2-one
  • Hispidine
  • 2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-hydroxy-4-pyranone
  • 2H-Pyran-2-one, 6-[(1E)-2-(3,4-dihydroxyphenyl)ethenyl]-4-hydroxy-
  • (E)-6-(3,4-Dihydroxystyryl)-4-hydroxy-2H-pyran-2-one
  • Endogenous Metabolite,inhibit,anti-dementia,anti-diabetic,fungal,properties,PKC,Hispidin,Protein kinase C,Inhibitor,anti-oxidant,anti-cancer,metabolite
  • 555-55-5