P-TOLYL-BETA-D-GLUCURONIDE

P-TOLYL-BETA-D-GLUCURONIDE Property

Melting point:

138-141°C

Boiling point:

549.7±50.0 °C(Predicted)

Density 

1.524±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

H₂O: 50 mg/mL, soluble

pka

2.80±0.70(Predicted)

form 

white powder

color 

White

biological source

synthetic

Safety

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

P-TOLYL-BETA-D-GLUCURONIDE Chemical Properties,Usage,Production

Uses

p-Cresol Glucuronide, is a metabolite of o-Cresol (C781910), which is a compound used as a disinfectant and have also been used as antiseptic in surgery.

Uses

P-TOLYL-BETA-D-GLUCURONIDE is a metabolite of o-Cresol (C781910), which is a compound used as a disinfectant and have also been used as antiseptic in surgery.

Definition

P-TOLYL-BETA-D-GLUCURONIDE is a glucosiduronic acid that is beta-D-glucuronic acid in which the anomeric hydroxyl hydrogen is replaced by a p-tolyl group.

Biological Activity

p-Cresol glucuronide is generated through a process called glucuronidation, which is a phase II metabolism reaction in the liver. In this process, p-cresol, a metabolite produced by the gut microbiota during the breakdown of dietary tyrosine and phenylalanine, undergoes conjugation with glucuronic acid. This conjugation is catalyzed by the enzyme UDP-glucuronosyltransferase (UGT) to form p-cresol glucuronide. The resulting glucuronide metabolite is then excreted in the urine. This process plays a crucial role in the elimination of p-cresol from the body.